ArticleNeuron2015
Stochastic Interaction between Neural Activity and Molecular Cues in the Formation of Topographic Maps.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Connectivity, Computation, and Plasticity of the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Article
- Postsynaptic NMDA Receptor Expression Is Required for Visual Corticocollicular Projection Refinement in the Mouse Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Segregation of Multimodal Inputs Into Discrete Midbrain Compartments During an Early Critical Period.Frontiers in neural circuits · 2022Article
- Wiring subcortical image-forming centers: Topography, laminar targeting, and map alignment.Current topics in developmental biology · 2021Review
- New insights on the modeling of the molecular mechanisms underlying neural maps alignment in the midbrain.eLife · 2020Article
- The U2AF2 /circRNA ARF1/miR-342-3p/ISL2 feedback loop regulates angiogenesis in glioma stem cells.Journal of experimental & clinical cancer research : CR · 2020Article
- Assembly and repair of eye-to-brain connections.Current opinion in neurobiology · 2018Review
- Theoretical Models of Neural Development.iScience · 2018Review
- Structural aspects of plasticity in the nervous system of Drosophila.Neural development · 2018Review
- Visual Maps Development: Reconsidering the Role of Retinal Efnas and Basic Principle of Map Alignment.Frontiers in cellular neuroscience · 2018Article
- Revisiting chemoaffinity theory: Chemotactic implementation of topographic axonal projection.PLoS computational biology · 2017Article
- Article
- Wiring visual systems: common and divergent mechanisms and principles.Current opinion in neurobiology · 2017Review
- Activity-dependent development of visual receptive fields.Current opinion in neurobiology · 2017Review
- Visual Neurons in the Superior Colliculus Innervated by Islet2Frontiers in neural circuits · 2017Article
- An evolving view of retinogeniculate transmission.Visual neuroscience · 2017Review
- Novel Models of Visual Topographic Map Alignment in the Superior Colliculus.PLoS computational biology · 2016Article
- Article
- Spatiotemporal Features of Retinal Waves Instruct the Wiring of the Visual Circuitry.Frontiers in neural circuits · 2016Review
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4 authors.
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Abstract
Topographic maps in visual processing areas maintain the spatial order of the visual world. Molecular cues and neuronal activity both play critical roles in map formation, but their interaction remains unclear. Here, we demonstrate that when molecular- and activity-dependent cues are rendered nearly equal in force, they drive topographic mapping stochastically. The functional and anatomical representation of azimuth in the superior colliculus of heterozygous Islet2-EphA3 knockin (Isl2(EphA3/+)) mice is variable: maps may be single, duplicated, or a combination of the two. This heterogeneity is not due to genetic differences, since map organizations in individual mutant animals often differ between colliculi. Disruption of spontaneous waves of retinal activity resulted in uniform map organization in Isl2(EphA3/+) mice, demonstrating that correlated spontaneous activity is required for map heterogeneity. Computational modeling replicates this heterogeneity, revealing that molecular- and activity-dependent forces interact simultaneously and stochastically during topographic map formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.