Evidence map›Paper›PMID 26402600›Full record

ReviewNeuron2015

Waking State: Rapid Variations Modulate Neural and Behavioral Responses.

Matthew J McGinley, Martin Vinck, Jacob Reimer, Renata Batista-Brito, Edward Zagha, Cathryn R Cadwell, Andreas S Tolias, Jessica A Cardin, David A McCormick

Abstract readReview
In one paragraph

Review in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 469 papers.

0numbers the graph read from it
0cells of the map it votes in
469citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

469 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Transcutaneous Auricular Vagus Nerve Stimulation Facilitates Cortical Arousal and Alertness.International journal of environmental research and public health · 2023
    Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Regulation of the decision threshold by the locus coeruleus.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  13. Article
  14. A claustro-cortical loop times state transitions for flexible behavior.bioRxiv : the preprint server for biology · 2026
    Article
  15. Auditory Cortex Distinguishes between Spontaneous and Sound-Evoked Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026
    Article
  20. Article

409 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew J McGinleyDepartment of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Martin VinckDepartment of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Jacob ReimerDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Renata Batista-BritoDepartment of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Edward ZaghaDepartment of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.
Cathryn R CadwellDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Andreas S ToliasDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: atolias@cns.bcm.edu.
Jessica A CardinDepartment of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA. Electronic address: jess.cardin@yale.edu.
David A McCormickDepartment of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA. Electronic address: david.mccormick@yale.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007330 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PLON, SHARON E. · 1985 to 2019
$15.6M
VISION RESEARCH CENTERP30EY002520 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Samuel M Wu · 1985 to 2026
$14.8M
Inhibitory regulation of cortical visual processingR01EY022951 · NEI · YALE UNIVERSITY · PI CARDIN, JESSICA A · 2013 to 2025
$4.0M
Neurotransmitter Actions in the Neocortex and ThalamusR01NS026143 · NINDS · YALE UNIVERSITY · PI MCCORMICK, DAVID · 1992 to 2016
$3.8M
VISUAL SCIENCEST32EY007001 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Samuel M Wu · 1985 to 2026
$3.7M
Dissecting the Fabric of the Cerebral CortexDP1EY023176 · NEI · BAYLOR COLLEGE OF MEDICINE · PI TOLIAS, ANDREAS · 2012 to 2015
$3.1M
Mechanisms of Rapid Modulation of Auditory ResponsivenessR01DC015803 · NIDCD · YALE UNIVERSITY · PI MCCORMICK, DAVID · 2017 to 2021
$1.6M
Dissecting the Fabric of the Cerebral CortexDP1OD008301 · OD · BAYLOR COLLEGE OF MEDICINE · PI TOLIAS, ANDREAS · 2011 to 2011
$783k
Impact of local network dynamics on visual cortex functionR00EY018407 · NEI · YALE UNIVERSITY · PI CARDIN, JESSICA A · 2010 to 2012
$727k
Training in Theoretical and Computational NeuroscienceT32EB006350 · NIBIB · BAYLOR COLLEGE OF MEDICINE · PI SAGGAU, PETER · 2007 to 2011
$693k
State dependent dynamics of sensory responses in auditory cortexF32DC012449 · NIDCD · YALE UNIVERSITY · PI MCGINLEY, MATTHEW J · 2012 to 2014
$107k
The Role of Cell Lineage in Determining Tuning Preferences in Visual CortexF30MH095440 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI CADWELL, CATHRYN RENE · 2013 to 2015
$81k
NCCDPHP CDC HHS DP1EY023176NEI NIH HHS DP1 EY023176NEI NIH HHS P30 EY002520NEI NIH HHS P30EY002520NEI NIH HHS R00 EY018407NEI NIH HHS R01 EY022951NEI NIH HHS T32 EY007001NEI NIH HHS T32EY07001NIBIB NIH HHS T32 EB006350NIBIB NIH HHS T32EB006350NIDCD NIH HHS F32 DC012449NIDCD NIH HHS R01 DC015803NIGMS NIH HHS T32 GM007330NIGMS NIH HHS T32GM007330NIH HHS DP1 OD008301NIH HHS DP1OD008301NIMH NIH HHS F30 MH095440NIMH NIH HHS F30MH095440NINDS NIH HHS R01 NS026143PHS HHS 5R01N2026143
6 · The paper itself

Abstract

The state of the brain and body constantly varies on rapid and slow timescales. These variations contribute to the apparent noisiness of sensory responses at both the neural and the behavioral level. Recent investigations of rapid state changes in awake, behaving animals have provided insight into the mechanisms by which optimal sensory encoding and behavioral performance are achieved. Fluctuations in state, as indexed by pupillometry, impact both the "signal" (sensory evoked response) and the "noise" (spontaneous activity) of cortical responses. By taking these fluctuations into account, neural response (co)variability is significantly reduced, revealing the brain to be more reliable and predictable than previously thought.

Indexed as

Action PotentialsAnimalsBrainHumansMotor ActivityNerve NetNeuronsTime FactorsWakefulness

Identifiers

PMID26402600
PMCPMC4718218

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.