Evidence map›Paper›PMID 26402459›Full record

ArticleeLife2015

Hippocampome.org: a knowledge base of neuron types in the rodent hippocampus.

Diek W Wheeler, Charise M White, Christopher L Rees, Alexander O Komendantov, David J Hamilton, Giorgio A Ascoli

Open access · goldAbstract read
In one paragraph

Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 179 citations in OpenAlex.

  1. Article
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  3. Hippocampome.org, a resource for subicular neuron types and beyond.bioRxiv : the preprint server for biology · 2025
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Diek W WheelerKrasnow Institute for Advanced Study, George Mason University, Fairfax, United States.ORCID http://orcid.org/0000-0001-8635-0033
Charise M WhiteKrasnow Institute for Advanced Study, George Mason University, Fairfax, United States.
Christopher L ReesKrasnow Institute for Advanced Study, George Mason University, Fairfax, United States.
Alexander O KomendantovKrasnow Institute for Advanced Study, George Mason University, Fairfax, United States.
David J HamiltonKrasnow Institute for Advanced Study, George Mason University, Fairfax, United States.ORCID http://orcid.org/0000-0001-6265-9917
Giorgio A AscoliKrasnow Institute for Advanced Study, George Mason University, Fairfax, United States.
George Mason University · US

Funding

Generation and Description of Neuronal Morphology and ConnectivityR01NS039600 · NINDS · GEORGE MASON UNIVERSITY · PI ASCOLI, GIORGIO A · 1999 to 2024
$6.9M
NINDS NIH HHS R01 NS039600NINDS NIH HHS R01NS39600
6 · The paper itself

Abstract

Hippocampome.org is a comprehensive knowledge base of neuron types in the rodent hippocampal formation (dentate gyrus, CA3, CA2, CA1, subiculum, and entorhinal cortex). Although the hippocampal literature is remarkably information-rich, neuron properties are often reported with incompletely defined and notoriously inconsistent terminology, creating a formidable challenge for data integration. Our extensive literature mining and data reconciliation identified 122 neuron types based on neurotransmitter, axonal and dendritic patterns, synaptic specificity, electrophysiology, and molecular biomarkers. All ∼3700 annotated properties are individually supported by specific evidence (∼14,000 pieces) in peer-reviewed publications. Systematic analysis of this unprecedented amount of machine-readable information reveals novel correlations among neuron types and properties, the potential connectivity of the full hippocampal circuitry, and outstanding knowledge gaps. User-friendly browsing and online querying of Hippocampome.org may aid design and interpretation of both experiments and simulations. This powerful, simple, and extensible neuron classification endeavor is unique in its detail, utility, and completeness.

Indexed as

Knowledge BasesRodentiaAnimalsHippocampusInformation Storage and RetrievalNeuronsdentate gyrusentorhinal cortexliterature miningmouseneural circuitneuronal classificationneurosciencepotential connectomerat

Identifiers

PMID26402459
PMCPMC4629441
OpenAlexW2138281354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.