ArticleJournal of biomedical materials research. Part A2016
Biphasic responses of human vascular smooth muscle cells to magnesium ion.
Article in Journal of biomedical materials research. Part A, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 80 citations in OpenAlex.
- Transcriptome Analysis, Machine Learning, and Experimental Identification of CDK7 Affecting the Progression of Pregnancy-induced Hypertension by Influencing Macrophage Polarization.Current molecular medicine · 2026Article
- Magnesium ion hydrogel enhances resistance to radiation-induced bone injury by modulating the bone immune microenvironment and promoting microvascularization.Regenerative biomaterials · 2025Article
- Magnesium Ion-Doped Mesoporous Bioactive Glasses Loaded with Gallic Acid Against Myocardial Ischemia/Reperfusion Injury by Affecting the Biological Functions of Multiple Cells.International journal of nanomedicine · 2024Article
- A "built-up" composite film with synergistic functionalities on Mg-2Zn-1Mn bioresorbable stents improves corrosion control effects and biocompatibility.Bioactive materials · 2023Article
- Improved mechanical, degradation, and biological performances of Zn-Fe alloys as bioresorbable implants.Bioactive materials · 2022Article
- Micro-Gel Ensembles for Accelerated Healing of Chronic Wound via pH Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Leptin and its relationship with magnesium biomarkers in women with obesity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- A Review on Manufacturing and Post-Processing Technology of Vascular Stents.Micromachines · 2022Review
- Amelioration of imiquimod-induced psoriasis-like dermatitis in mice by DSW therapy inspired hydrogel.Bioactive materials · 2021Article
- The Fabrication of a Gellan Gum-Based Hydrogel Loaded With Magnesium Ions for the Synergistic Promotion of Skin Wound Healing.Frontiers in bioengineering and biotechnology · 2021Article
- Metallic Ions Encapsulated in Electrospun Nanofiber for Antibacterial and Angiogenesis Function to Promote Wound Repair.Frontiers in cell and developmental biology · 2021Article
- Nano-micrometer surface roughness gradients reveal topographical influences on differentiating responses of vascular cells on biodegradable magnesium.Bioactive materials · 2021Article
- Wound Healing Activity of Nanoclay/Spring Water Hydrogels.Pharmaceutics · 2020Article
- Salt Preform Texturing of Absorbable Zn Substrates for Bone-implant Applications.JOM (Warrendale, Pa. : 1989) · 2020Article
- Recent Advances in Manufacturing Innovative Stents.Pharmaceutics · 2020Review
- Evolution of metallic cardiovascular stent materials: A comparative study among stainless steel, magnesium and zinc.Biomaterials · 2020Article
- Enhanced cytocompatibility and antibacterial property of zinc phosphate coating on biodegradable zinc materials.Acta biomaterialia · 2019Article
- Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Interfacial Zinc Phosphate is the Key to Controlling Biocompatibility of Metallic Zinc Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Biodegradable Magnesium Alloy Stents as a Treatment for Vein Graft Restenosis.Yonsei medical journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Magnesium-based alloys are promising in biodegradable cardiovascular stent applications. The degradation products of magnesium stents may have significant impacts on the surrounding vascular cells. However, knowledge on the interactions between magnesium ion and vascular cells at the molecular and cellular levels is still largely missing. Vascular smooth muscle cell (SMC) plays an important role in the pathogenesis of restenosis and wound healing after stent implantation. This study evaluated the short-term effects of extracellular magnesium ion (Mg(2+)) on the cellular behaviors of SMCs. Cellular responses to Mg(2+) were biphasic and in a concentration-dependent manner. Low concentrations (10 mM) of Mg(2+) increased cell viability, cell proliferation rate, cell adhesion, cell spreading, cell migration rate, and actin expression. In contrast, higher concentrations (40-60 mM) of Mg(2+) had deleterious effects on cells. Gene expression analysis revealed that Mg(2+) altered the expressions of genes mostly related to cell adhesion, cell injury, angiogenesis, inflammation, coagulation, and cell growth. Finding from this study provides some valuable information on SMC responses toward magnesium ions at the cellular and molecular levels, and guidance for future controlled release of magnesium from the stent material.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.