Evidence map›Paper›PMID 26402404›Full record

ReviewCurrent opinion in neurology2015

Dose and timing in neurorehabilitation: prescribing motor therapy after stroke.

Catherine E Lang, Keith R Lohse, Rebecca L Birkenmeier

3 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 129 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 10 pooled it
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01146379 phase2completednot on this map

Dose Response of Movement Practice During Stroke Rehabilitation

TypeinterventionalSponsorWashington University School of MedicineRan2010 to 2015Enrolled85ConditionsStrokeArmsIntensive task-specific upper extremity rehabilitation
NCT04304976 nacompletednot on this mapstarted 2019, after this paper: background citation

Clinical Trial ROBERT® - Project Active Training

TypeinterventionalSponsorLifescience-RoboticsRan2019 to 2020Enrolled8ConditionsApoplexy, Stroke, Spinal Cord Injuries, SafetyArmsROBERT®
NCT06234124 narecruitingnot on this mapstarted 2024, after this paper: background citation

Characterization and Clinical Trial of a Variable Friction Shoe, a New Paradigm of Reduced-constraint Locomotor Therapy for People Exhibiting Foot Drop Due to Stroke

TypeinterventionalSponsorShirley Ryan AbilityLabRan2024 to 2027Enrolled50ConditionsStrokeArmsVariable Friction Shoe Training, Ankle Foot Orthosis (AFO) Training
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 10 syntheses or guidelines pooled it, 257 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Dosage Matters.Stroke · 2019
    Trial

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Catherine E LangaProgram in Physical Therapy bProgram in Occupational Therapy, Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri cSchool of Kinesiology, Auburn University, Auburn, Alabama, USA.
Keith R Lohse
Rebecca L Birkenmeier
American Physical Therapy Association · USAuburn University · USL'Alliance Boviteq · CA

Funding

Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2015 to 2019
$7.1M
Translation of in-clinic Gains to Gains in Daily Life After StrokeR01HD068290 · NICHD · WASHINGTON UNIVERSITY · PI LANG, CATHERINE · 2012 to 2021
$4.0M
Translation of In-Clinic Gains to Gains in Daily LifeR37HD068290 · NICHD · WASHINGTON UNIVERSITY · PI Catherine Lang · 2022 to 2026
$2.7M
NICHD NIH HHS R01 HD068290NICHD NIH HHS R01HD068290NICHD NIH HHS R37 HD068290NICHD NIH HHS U54 HD087011
6 · The paper itself

Abstract

purpose of reviewPrescribing the most appropriate dose of motor therapy for individual patients is a challenge because minimal data are available and a large number of factors are unknown. This review explores the concept of dose and reviews the most recent findings in the field of neurorehabilitation, with a focus on relearning motor skills after stroke. RECENT

findingsAppropriate dosing involves the prescription of a specific amount of an active ingredient, at a specific frequency and duration. Dosing parameters, particularly amount, are not well defined or quantified in most studies. Compiling data across studies indicates a positive, moderate dose-response relationship, indicating that more movement practice results in better outcomes. This relationship is confounded by time after stroke, however, wherein longer durations of scheduled therapy may not be beneficial in the first few hours, days, and/or weeks. SUMMARY: These findings suggest that substantially more movement practice may be necessary to achieve better outcomes for people living with the disabling consequences of stroke. Preclinical investigations are needed to elucidate many of the unknowns and allow for a more biologically driven rehabilitation prescription process. Likewise, clinical investigations are needed to determine the dose-response relationships and examine the potential dose-timing interaction in humans.

Indexed as

Stroke RehabilitationExercise TherapyHumansNeurological Rehabilitation

Identifiers

PMID26402404
PMCPMC4643742
OpenAlexW2413064041

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.