Evidence map›Paper›PMID 26402349›Full record

ArticleJournal of studies on alcohol and drugs2015

Genetic and Environmental Predictors of Alcohol Use in Asian American Young Adults.

Spencer Bujarski, Anna S Lau, Steve S Lee, Lara A Ray

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of studies on alcohol and drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. ALDH2*2 and peer drinking in East Asian college students.The American journal of drug and alcohol abuse · 2017
    Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Spencer BujarskiDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.
Anna S LauDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.
Steve S LeeDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.
Lara A RayDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.
University of California, Los Angeles · US

Funding

ZDV &3TC NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFECTED INFANTS &M01RR000865 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WASHINGTON, ARNOLD E. · 1985 to 2011
$43.4M
Subjective Response and Self-Administration of Alcohol in the Human LabF31AA022569 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUJARSKI, SPENCER · 2014 to 2015
$69k
NCRR NIH HHS M01 RR000865NCRR NIH HHS M01 RR00865NIAAA NIH HHS F31 AA022569
6 · The paper itself

Abstract

objectiveAmong Asian American young adults, variations in alcohol-metabolizing genes (i.e., aldehyde dehydrogenase [ALDH2] and alcohol dehydrogenase [ADH1B]) are protective, whereas Korean ethnicity, family history of alcohol problems (FH), and acculturation represent risk factors for alcohol misuse. This study aims to integrate these genetic and environmental factors in a sample of Asian Americans expressing a wide range of alcohol use behaviors and problems.

methodParticipants were 97 Asian American young adults (42% female) recruited as heavy and light drinkers (n = 49 and 48, respectively). Participants completed the Alcohol Use Disorders Identification Test, Timeline Followback, Vancouver Acculturation Index, and Family Tree Questionnaire. All participants provided buccal cell samples for DNA analysis.

resultsFamily history-positive (FH+) subjects reported greater alcohol use than family history-negative (FH-) subjects. A FH × ALDH2 interaction was observed such that FH- subjects demonstrated no ALDH2 effect, yet in FH+ subjects, the ALDH2*2 genotype was associated with increased alcohol use. A significant main effect of acculturation was also moderated by FH such that the positive association between acculturation and alcohol use was greater among FH+ subjects and, in particular, among FH+ men.

conclusionsAlthough preliminary, these results suggest that the potential protective effects conferred by ALDH2 and ADH1B are moderated by FH, such that a positive FH appeared to abolish the protective effect of these genes. Further, acculturation was associated with greater alcohol use in FH+ subjects only. If replicated in larger samples, these data suggest that alcohol-metabolism genes may not be protective in the context of high environmental risk.

Indexed as

AcculturationAdultAlcohol DehydrogenaseAlcohol DrinkingAldehyde DehydrogenaseAsianEnvironmentFemaleGenotypeHumansMaleRisk FactorsSurveys and QuestionnairesYoung AdultAlcohol DehydrogenaseAldehyde Dehydrogenase

Identifiers

PMID26402349
PMCPMC4714821
OpenAlexW2189465564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.