Evidence map›Paper›PMID 26401991›Full record

GuidelineArthritis & rheumatology (Hoboken, N.J.)2016

American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.

Michael M Ward, Atul Deodhar, Elie A Akl, Andrew Lui, Joerg Ermann, Lianne S Gensler, Judith A Smith, David Borenstein, Jayme Hiratzka, Pamela F Weiss and 17 more

Registry-linked trialOpen access · bronzeAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Arthritis & rheumatology (Hoboken, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05504616 (Physical Activity in Axial Spondyloarthritis), which is not on this map. Cited by 191 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
191citing papers in PubMed, 15 pooled it
45.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05504616 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Physical Activity in Axial Spondyloarthritis: Development and Implementation of an Evidence-Based Health Technology Approach to Improve Adherence to Recommended Guidelines

TypeinterventionalSponsorUniversity Health Network, TorontoRan2022 to 2024Enrolled106ConditionsAxial SpondyloarthritisArmsHealth technology-based intervention strategy
3 · Its place in the literature

Who cites it

191 citing papers in PubMed, 15 syntheses or guidelines pooled it, 546 citations in OpenAlex.

  1. Guideline
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131 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 20 institutions in 4 countries.

Michael M WardNational Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland.
Atul DeodharOregon Health & Science University, Portland.
Elie A AklAmerican University of Beirut, Beirut, Lebanon, and McMaster University, Hamilton, Ontario, Canada.
Andrew LuiUniversity of California, San Francisco.
Joerg ErmannBrigham and Women's Hospital, Boston, Massachusetts.
Lianne S GenslerUniversity of California, San Francisco.
Judith A SmithUniversity of Wisconsin, Madison.
David BorensteinArthritis and Rheumatism Associates, Washington, DC.
Jayme HiratzkaOregon Health & Science University, Portland.
Pamela F WeissChildren's Hospital of Philadelphia and University of Pennsylvania, Philadelphia.
Robert D InmanUniversity of Toronto, Toronto, Ontario, Canada.
Vikas MajithiaUniversity of Mississippi Medical Center, Jackson.
Nigil HaroonUniversity of Toronto, Toronto, Ontario, Canada.
Walter P MaksymowychUniversity of Alberta, Edmonton, Alberta, Canada.
Janet JoyceAmerican College of Rheumatology, Atlanta, Georgia.
Bruce M ClarkVancouver, British Columbia, Canada.
Robert A ColbertNational Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland.
Mark P FiggieHospital for Special Surgery, New York, New York.
David S HalleguaCedars-Sinai Medical Center, Beverly Hills, California.
Pamela E PreteVA Long Beach Medical Center, Long Beach, California, and University of California, Irvine.
James T RosenbaumOregon Health & Science University and Legacy Devers Eye Institute, Portland.
Judith A StebulisUniversity of Massachusetts, Worcester.
Filip van den BoschUniversity of Ghent, Ghent, Belgium.
David T Y YuUniversity of California, Los Angeles.
Amy S MillerAmerican College of Rheumatology, Atlanta, Georgia.
John D ReveilleUniversity of Texas Health Sciences Center at Houston.
Liron CaplanDenver VA Medical Center, Denver, Colorado, and University of Colorado, Aurora.
American College of Rheumatology · USNational Institute of Arthritis and Musculoskeletal and Skin Diseases · USOregon Health & Science University · USUniversity of California, San Francisco · USUniversity of Toronto · CAArthritis and Rheumatism Associates · USBrigham and Women's Hospital · USCedars-Sinai Medical Center · USGhent University Hospital · BEHospital for Special Surgery · USLegacy Health · USLong Beach Medical Center · USMcMaster University · CAThe University of Texas Health Science Center at Houston · USUniversity of Alberta · CAUniversity of California, Los Angeles · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Massachusetts Chan Medical School · USUniversity of Mississippi Medical Center · USUniversity of Pennsylvania · US

Funding

Pathogenic Mechanisms in SpondyloarthritisZIAAR041184 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI COLBERT, ROBERT · 2009 to 2025
$47.6M
Outcomes in Rheumatic DiseasesZIAAR041153 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI WARD, MICHAEL · 2009 to 2020
$12.6M
Outcomes in Rheumatic DiseasesZ01AR041153 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI WARD, MICHAEL · 2005 to 2008
$1.6M
Intramural NIH HHS Z01 AR041153
6 · The paper itself

Abstract

objectiveTo provide evidence-based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spondyloarthritis (SpA).

methodsA core group led the development of the recommendations, starting with the treatment questions. A literature review group conducted systematic literature reviews of studies that addressed 57 specific treatment questions, based on searches conducted in OVID Medline (1946-2014), PubMed (1966-2014), and the Cochrane Library. We assessed the quality of evidence using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) method. A separate voting group reviewed the evidence and voted on recommendations for each question using the GRADE framework.

resultsIn patients with active AS, the strong recommendations included use of nonsteroidal antiinflammatory drugs (NSAIDs), use of tumor necrosis factor inhibitors (TNFi) when activity persists despite NSAID treatment, not to use systemic glucocorticoids, use of physical therapy, and use of hip arthroplasty for patients with advanced hip arthritis. Among the conditional recommendations was that no particular TNFi was preferred except in patients with concomitant inflammatory bowel disease or recurrent iritis, in whom TNFi monoclonal antibodies should be used. In patients with active nonradiographic axial SpA despite treatment with NSAIDs, we conditionally recommend treatment with TNFi. Other recommendations for patients with nonradiographic axial SpA were based on indirect evidence and were the same as for patients with AS.

conclusionThese recommendations provide guidance for the management of common clinical questions in AS and nonradiographic axial SpA. Additional research on optimal medication management over time, disease monitoring, and preventive care is needed to help establish best practices in these areas.

Indexed as

Arthroplasty, Replacement, HipPhysical Therapy ModalitiesAdalimumabAnti-Inflammatory Agents, Non-SteroidalAntirheumatic AgentsEtanerceptEvidence-Based MedicineGlucocorticoidsHumansInflammatory Bowel DiseasesInfliximabRadiographyRheumatologySocieties, MedicalSpondylarthritisSpondylarthropathiesAdalimumabAnti-Inflammatory Agents, Non-SteroidalAntirheumatic AgentsEtanerceptGlucocorticoidsInfliximabTumor Necrosis Factor-alpha

Identifiers

PMID26401991
PMCPMC5123840
OpenAlexW2097209079

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.