Evidence map›Paper›PMID 26401979›Full record

ArticlePain management2015

What effect can manual therapy have on a patient's pain experience?

Mark D Bishop, Rafael Torres-Cueco, Charles W Gay, Enrique Lluch-Girbés, Jason M Beneciuk, Joel E Bialosky

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05780593 (Effects of Manual Therapy and Inclined Board Standing on Low Back Pain), which is not on this map. Cited by 81 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05780593 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Manual Therapy and Inclined Board Standing on Low Back Pain

TypeinterventionalSponsorAgile Institute of Rehabilitation SciencesRan2023 to 2023Enrolled44ConditionsLow Back PainArmsManual Therapy, Inclined Board Standing
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  9. Can Manual Therapy Alter Muscle Stiffness in Patients With Spinal Accessory Nerve Injury?Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mark D BishopDepartment of Physical Therapy, PO Box 100154, University of Florida, Gainesville, FL 32610, USA.
Rafael Torres-CuecoDepartment of Physical Therapy, University of Valencia, Av. de Blasco Ibáñez, 13, 46010 València, Spain.
Charles W GayDepartment of Physical Therapy, PO Box 100154, University of Florida, Gainesville, FL 32610, USA.
Enrique Lluch-GirbésDepartment of Physical Therapy, University of Valencia, Av. de Blasco Ibáñez, 13, 46010 València, Spain.
Jason M BeneciukDepartment of Physical Therapy, PO Box 100154, University of Florida, Gainesville, FL 32610, USA.
Joel E BialoskyDepartment of Physical Therapy, PO Box 100154, University of Florida, Gainesville, FL 32610, USA.

Funding

Rehabilitation Research Career Development ProgramK12HD055929 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BROWN, DAVID A · 2007 to 2021
$11.7M
Central Mechanisms of Body Based Intervention for Musculoskeletal Low Back PainR01AT006334 · NCCIH · UNIVERSITY OF FLORIDA · PI BISHOP, MARK D. · 2011 to 2015
$1.6M
CENTRAL MECHANISMS OF MANIPULATIVE AND BODY-BASED INTERVENTIONS: TRAINING PROGRAMF32AT007729 · NCCIH · UNIVERSITY OF FLORIDA · PI PENZA, CHARLES W · 2013 to 2015
$200k
NCCIH NIH HHS F32 AT007729NCCIH NIH HHS R01 AT006334NCCIH NIH HHS R01AT006334NICHD NIH HHS K12 HD055929NICHD NIH HHS K12HD055929
6 · The paper itself

Abstract

Manual therapy (MT) is a passive, skilled movement applied by clinicians that directly or indirectly targets a variety of anatomical structures or systems, which is utilized with the intent to create beneficial changes in some aspect of the patient pain experience. Collectively, the process of MT is grounded on clinical reasoning to enhance patient management for musculoskeletal pain by influencing factors from a multidimensional perspective that have potential to positively impact clinical outcomes. The influence of biomechanical, neurophysiological, psychological and nonspecific patient factors as treatment mediators and/or moderators provides additional information related to the process and potential mechanisms by which MT may be effective. As healthcare delivery advances toward personalized approaches there is a crucial need to advance our understanding of the underlying mechanisms associated with MT effectiveness.

Indexed as

Pain ManagementPhysical Therapy ModalitiesAnimalsCerebral CortexClinical Trials as TopicFemaleHumansInflammation MediatorsMaleMusculoskeletal PainPain PerceptionSpinal CordTreatment OutcomeInflammation Mediatorsbiomechanicalclinical reasoningeffectivenessexpectationneurophysiologicalplacebopreferencepsychologicaltreatment mediationtreatment moderation

Identifiers

PMID26401979
PMCPMC4976880

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.