ArticleInternational braz j urol : official journal of the Brazilian Society of Urology
Decline in semen quality among infertile men in Brazil during the past 10 years.
Article in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effectiveness of different down-regulating protocols on in vitro fertilization-embryo transfer in endometriosis: a meta-analysis.Reproductive biology and endocrinology : RB&E · 2020Pooled it
- Oxidative Stress and Male Reproductive Health-First Edition.Antioxidants (Basel, Switzerland) · 2026Article
- Epidemiological characteristics and temporal trends of male infertility in Egypt (2012-2022): Analysis of 3,037 consecutive cases.Arab journal of urology · 2026Article
- Semen quality of male partners of infertile couples attending a private specialist infertility hospital in Kumasi, Ghana: a retrospective descriptive analysis.The Pan African medical journal · 2025Article
- Machine learning-based clustering to identify the combined effect of the DNA fragmentation index and conventional semen parameters on in vitro fertilization outcomes.Reproductive biology and endocrinology : RB&E · 2023Article
- Decline of Sperm Quality over the Last Two Decades in the South of Europe: A Retrospective Study in Infertile Patients.Biology · 2022Article
- Spatiotemporal trends in human semen quality.Nature reviews. Urology · 2022Review
- Is seminal quality worsening? A 20-year experience in Córdoba, Argentina.Journal of assisted reproduction and genetics · 2022Article
- Sperm donor lifestyle survey: modifiable risk factors for potential sperm donors.Journal of assisted reproduction and genetics · 2021Article
- Decline of semen quality over the last 30 years in Uruguay.Basic and clinical andrology · 2021Article
- Unbalance of Se and nutritional status in male infertility.JBRA assisted reproduction · 2021Article
- Temporal Trend of Conventional Sperm Parameters in a Sicilian Population in the Decade 2011-2020.Journal of clinical medicine · 2021Article
- Shorter ejaculatory abstinence interval and maternal endometrium exposure to seminal plasma as tools to improve pregnancy rate in patients undergoing intracytoplasmic sperm injection cycles.JBRA assisted reproduction · 2018Article
- Fertility counseling and preservation: considerations for the pediatric endocrinologist.Translational pediatrics · 2017Review
- Melatonin ameliorates restraint stress-induced oxidative stress and apoptosis in testicular cells via NF-κB/iNOS and Nrf2/ HO-1 signaling pathway.Scientific reports · 2017Article
- Article
- Are semen parameters worsening? Comparing semen parameters 10 years apart.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
- Will male semen quality improve with environmental quality?Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate whether the semen quality of men undergoing conventional semen analysis is deteriorating over time. MATERIALS AND
methodsWe analyzed and compared the sperm count, motility and morphology of 2300 semen samples provided by males undergoing conventional seminal analysis, from years 2000 to 2002 and 2010 to 2012. The incidences of severe oligozoospermia and azoospermia over time were also compared.
resultsA total of 764 sperm samples were analyzed in 2000-2002 and 1536 in 2010-2012. Over time, the mean sperm concentration/ml decreased significantly from 61.7 million in 2000-2002 to 26.7 million in 2010-2012 (R2 = 11.4%, p < 0.001), the total sperm concentration decreased significantly from 183.0 million to 82.8 million (R2 = 11.3%, p < 0.001), and the percentage of normal forms decreased significantly from 4.6% to 2.7% (R2 = 9.8%, p < 0.001). The incidence of severe oligozoospermia significantly increased from 15.7% to 30.3% (OR: 1.09, p < 0.001) and the incidence of azoospermia increased from 4.9% to 8.5% (OR: 1.06, p = 0.001).
conclusionsThis study demonstrated a significant time-related decline in semen quality of infertile patients. This finding might have implications on fertility and emphasizes the need for further studies addressing subject's life-style in order to find and reduce the causative agents. Future prospective and multicenter studies including representative samples of the general population are needed to confirm whether semen quality is really declining.
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