ArticlePLoS genetics2015
Arabidopsis AtPLC2 Is a Primary Phosphoinositide-Specific Phospholipase C in Phosphoinositide Metabolism and the Endoplasmic Reticulum Stress Response.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Primary nitrate responses mediated by calcium signalling and diverse protein phosphorylation.Journal of experimental botany · 2020Pooled it
- Loss of AtPLC1 Impairs Salt-Alkali Tolerance via Disruption of Stomatal Regulation and Redox Homeostasis inPlants (Basel, Switzerland) · 2026Article
- A Rhamnogalacturonan Acetylesterase Effector FsRGAE1 Enhances the Virulence ofJournal of fungi (Basel, Switzerland) · 2026Article
- Linking redox and calcium signaling via thioredoxins.Journal of experimental botany · 2026Review
- A Fusarium sacchari Glycoside Hydrolase 12 Protein FsEG1 Is a Major Virulence Factor During Sugarcane Infection and Confers Resistance to Pokkah Boeng Disease via the HIGS Strategy.Plant biotechnology journal · 2026Article
- Integrated transcriptomic and metabolomic analysis of prohexadione calcium-mediated alleviation of salt stress in oilseed rape (Brassica napus L.) seedlings.BMC plant biology · 2026Article
- Concerted transport and phosphorylation of diacylglycerol at ER-PM contact sites regulate phospholipid dynamics during stress.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genomic introgression underlies environmental adaptation in three species of Chinese wingnuts,Plant diversity · 2025Article
- Plant PI-PLC signaling in stress and development.Plant physiology · 2025Review
- Genome-wide identification of the PI-PLC gene family inFrontiers in plant science · 2025Article
- The VAMP-associated protein VAP27-1 plays a crucial role in plant resistance to ER stress by modulating ER-PM contact architecture in Arabidopsis.Plant communications · 2024Article
- Ectopic Expression of Distinct PLC Genes Identifies 'Compactness' as a Possible Architectural Shoot Strategy to Cope with Drought Stress.Plant & cell physiology · 2024Article
- Genetic interaction between TTG2 and AtPLC1 reveals a role for phosphoinositide signaling in a co-regulated suite of Arabidopsis epidermal pathways.Scientific reports · 2024Article
- Exploring the Role ofInternational journal of molecular sciences · 2023Article
- CRISPR/Cas9-mediated phospholipase C 2 knock-out tomato plants are more resistant to Botrytis cinerea.Planta · 2023Article
- Phosphoinositides in plant-pathogen interaction: trends and perspectives.Stress biology · 2023Review
- Physiological responses induced by phospholipase C isoform 5 upon heat stress inFrontiers in plant science · 2023Article
- Coupling VIGS with Short- and Long-Term Stress Exposure to Understand the Fiskeby III Iron Deficiency Stress Response.International journal of molecular sciences · 2022Article
- Mitochondrial Complex I Disruption Causes Broad Reorchestration of Plant Lipidome Including Chloroplast Lipids.International journal of molecular sciences · 2022Article
- Advances in Plant Lipid Metabolism Responses to Phosphate Scarcity.Plants (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphoinositides represent important lipid signals in the plant development and stress response. However, multiple isoforms of the phosphoinositide biosynthetic genes hamper our understanding of the pivotal enzymes in each step of the pathway as well as their roles in plant growth and development. Here, we report that phosphoinositide-specific phospholipase C2 (AtPLC2) is the primary phospholipase in phosphoinositide metabolism and is involved in seedling growth and the endoplasmic reticulum (ER) stress responses in Arabidopsis thaliana. Lipidomic profiling of multiple plc mutants showed that the plc2-1 mutant increased levels of its substrates phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate, suggesting that the major phosphoinositide metabolic pathway is impaired. AtPLC2 displayed a distinct tissue expression pattern and localized at the plasma membrane in different cell types, where phosphoinositide signaling occurs. The seedlings of plc2-1 mutant showed growth defect that was complemented by heterologous expression of AtPLC2, suggesting that phosphoinositide-specific phospholipase C activity borne by AtPLC2 is required for seedling growth. Moreover, the plc2-1 mutant showed hypersensitive response to ER stress as evidenced by changes in relevant phenotypes and gene expression profiles. Our results revealed the primary enzyme in phosphoinositide metabolism, its involvement in seedling growth and an emerging link between phosphoinositide and the ER stress response.
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