Trial reportJournal of perinatology : official journal of the California Perinatal Association2016
Timing of umbilical cord clamping among infants born at 22 through 27 weeks' gestation.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- 2025 Korean Guidelines for Cardiopulmonary Resuscitation: Part 9. Neonatal resuscitation.Clinical and experimental emergency medicine · 2026Guideline
- The effect of delayed cord clamping on early cardiac and cerebral hemodynamics, mortality, and severe intraventricular hemorrhage in preterm infants < 32 weeks: a systematic review and meta-analysis of clinical trials.European journal of pediatrics · 2025Pooled it
- Umbilical cord milking and delayed cord clamping for the prevention of neonatal hypoglycaemia: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- Interventions to Reduce Severe Brain Injury Risk in Preterm Neonates: A Systematic Review and Meta-analysis.JAMA network open · 2023Pooled it
- Antenatal and perinatal factors influencing neonatal blood pressure: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2021Pooled it
- Eligibility Criteria and Representativeness of Randomized Clinical Trials That Include Infants Born Extremely Premature: A Systematic Review.The Journal of pediatrics · 2021Pooled it
- Pooled it
- Interventions to minimize blood loss in very preterm infants-A systematic review and meta-analysis.PloS one · 2021Pooled it
- Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.The Cochrane database of systematic reviews · 2019Pooled it
- [Interpretation of 2023 American Heart Association and American Academy of Pediatrics focused update on neonatal resuscitation guidelines].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- A survey on management practices of hypotension in preterm neonates: an Indian perspective.Frontiers in pediatrics · 2024Article
- Implementation of Delayed Cord Clamping in public health facilities: a case study from India.BMC pregnancy and childbirth · 2022Article
- Maintaining Normothermia in Preterm Babies during Stabilisation with an Intact Umbilical Cord.Children (Basel, Switzerland) · 2022Article
- Article
- An Immature Science: Intensive Care for Infants Born at ≤23 Weeks of Gestation.The Journal of pediatrics · 2021Review
- Association of Deferred vs Immediate Cord Clamping With Severe Neurological Injury and Survival in Extremely Low-Gestational-Age Neonates.JAMA network open · 2019Article
- Transitional fetal hemodynamics and gas exchange in premature postpartum adaptation: immediate vs. delayed cord clamping.Maternal health, neonatology and perinatology · 2019Article
- Clinical aspects of incorporating cord clamping into stabilisation of preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2018Review
- Italian Recommendations for Placental Transfusion Strategies.Frontiers in pediatrics · 2018Review
- Placental Transfusion and Cardiovascular Instability in the Preterm Infant.Frontiers in pediatrics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveTo investigate the safety, feasibility and efficacy of delayed cord clamping (DCC) compared with immediate cord clamping (ICC) at delivery among infants born at 22 to 27 weeks' gestation. STUDY
designThis was a pilot, randomized, controlled trial in which women in labor with singleton pregnancies at 22 to 27 weeks' gestation were randomly assigned to ICC (cord clamped at 5 to 10 s) or DCC (30 to 45 s).
resultsForty mother-infant pairs were randomized. Infants in the ICC and DCC groups had mean gestational ages (GA) of 24.6 and 24.4 weeks, respectively. No differences were observed between the groups across all available safety measures, although infants in the DCC group had higher admission temperatures than infants in the ICC group (97.4 vs. 96.2 °F, P=0.04). During the first 24 h of life, blood pressures were lower in the ICC group than in the DCC group (P<0.05), despite a threefold greater incidence of treatment for hypotension (45% vs. 12%, P<0.01). Infants in the ICC group had increased numbers of red blood transfusions (in first 28 days of life) than infants in DCC group (4.1±3.9 vs. 2.8±2.2, P=0.04).
conclusionAmong infants born at an average GA of 24 weeks', DCC appears safe, logistically feasible, and offers hematological and circulatory advantages compared with ICC. A more comprehensive appraisal of this practice is needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.