Evidence map›Paper›PMID 26401685›Full record

ArticleACS nano2015

Plasmonic Nanopores for Trapping, Controlling Displacement, and Sequencing of DNA.

Maxim Belkin, Shu-Han Chao, Magnus P Jonsson, Cees Dekker, Aleksei Aksimentiev

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 198 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Recent advances in single-particle analysis with nanopore technology.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Plasmonic Nanostructure Biosensors: A Review.Sensors (Basel, Switzerland) · 2023
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Localized Nanopore Fabrication via Controlled Breakdown.Nanomaterials (Basel, Switzerland) · 2022
    Review
  19. Article
  20. Single-Molecule Surface-Enhanced Raman Spectroscopy.Sensors (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 4 countries.

Maxim BelkinDepartment of Physics, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Shu-Han ChaoDepartment of Physics, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Magnus P JonssonOrganic Electronics, Department of Science and Technology (ITN), Linköping University , SE-58183 Linköping, Sweden.
Cees DekkerDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology , 2628 CJ Delft, The Netherlands.
Aleksei AksimentievDepartment of Physics, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
University of Illinois Urbana-Champaign · USDelft University of Technology · NLDepartment of Science and Technology · IN

Funding

WHOLE CELL SIMULATIONP41RR005969 · NCRR · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI STONE, JOHN H · 1990 to 2011
$19.8M
Plasmonic nanopores for trapping, controlled motion and sequencing of DNAR01HG007406 · NHGRI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI AKSIMENTIEV, ALEKSEI · 2013 to 2016
$2.4M
NCRR NIH HHS P41 RR005969NCRR NIH HHS P41-RR005969NHGRI NIH HHS R01 HG007406NHGRI NIH HHS R01-HG007406
6 · The paper itself

Abstract

With the aim of developing a DNA sequencing methodology, we theoretically examine the feasibility of using nanoplasmonics to control the translocation of a DNA molecule through a solid-state nanopore and to read off sequence information using surface-enhanced Raman spectroscopy. Using molecular dynamics simulations, we show that high-intensity optical hot spots produced by a metallic nanostructure can arrest DNA translocation through a solid-state nanopore, thus providing a physical knob for controlling the DNA speed. Switching the plasmonic field on and off can displace the DNA molecule in discrete steps, sequentially exposing neighboring fragments of a DNA molecule to the pore as well as to the plasmonic hot spot. Surface-enhanced Raman scattering from the exposed DNA fragments contains information about their nucleotide composition, possibly allowing the identification of the nucleotide sequence of a DNA molecule transported through the hot spot. The principles of plasmonic nanopore sequencing can be extended to detection of DNA modifications and RNA characterization.

Indexed as

NanoporesSequence Analysis, DNABase SequenceDNADNA, Single-StrandedMolecular Dynamics SimulationSpectrum Analysis, RamanDNADNA, Single-StrandedDNA sequencingmolecular dynamicsnanoplasmonicsnanoporeplasmonic tweezers

Identifiers

PMID26401685
PMCPMC4660389
OpenAlexW2233819953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.