SynthesisJournal of Alzheimer's disease : JAD2015
Multimodal Voxel-Based Meta-Analysis of White Matter Abnormalities in Alzheimer's Disease.
Synthesis in Journal of Alzheimer's disease : JAD, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Revolutionizing early Alzheimer's disease and mild cognitive impairment diagnosis: a deep learning MRI meta-analysis.Arquivos de neuro-psiquiatria · 2024Pooled it
- Identification and validation of supervariants reveal novel loci associated with human white matter microstructure.Genome research · 2024Pooled it
- A Comparative Multimodal Meta-analysis of Anisotropy and Volume Abnormalities in White Matter in People Suffering From Bipolar Disorder or Schizophrenia.Schizophrenia bulletin · 2022Pooled it
- Systematic Review of Different Neuroimaging Correlates in Mild Cognitive Impairment and Alzheimer's Disease.Clinical neuroradiology · 2021Pooled it
- Atrophy in midbrain & cerebral/cerebellar pedunculi is characteristic for progressive supranuclear palsy - A double-validation whole-brain meta-analysis.NeuroImage. Clinical · 2019Pooled it
- White matter microstructural and macrostructural profiles during midlife reveal sex differences between men and women at different menopausal stages.Scientific reports · 2025Article
- Association between neuroticism and brain-wide structural outcomes: Mediation by vascular and mental conditions.Psychological medicine · 2025Article
- Harmonizing 10,000 connectomes: site-invariant representation learning for multi-site analysis of network connectivity and cognitive impairment.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- An investigation on Alzheimer's disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure.Frontiers in aging neuroscience · 2025Article
- Structural disruption in subjective cognitive decline and mild cognitive impairment.Brain imaging and behavior · 2024Article
- Neuromodulatory subcortical nucleus integrity is associated with white matter microstructure, tauopathy and APOE status.Nature communications · 2024Article
- Comprehensive assessment of sleep duration, insomnia, and brain structure within the UK Biobank cohort.Sleep · 2024Article
- Reproducible Abnormalities and Diagnostic Generalizability of White Matter in Alzheimer's Disease.Neuroscience bulletin · 2023Article
- Source connectivity patterns in the default mode network differ between elderly golf-novices and non-golfers.Scientific reports · 2023Article
- An examination of Alzheimer's disease and white matter from 1981 to 2023: a Bibliometric and visual analysis.Frontiers in neurology · 2023Article
- Effect of sex on the APOE4-aging interaction in the white matter microstructure of cognitively normal older adults using diffusion-tensor MRI with orthogonal-tensor decomposition (DT-DOME).Frontiers in neuroscience · 2023Article
- Neuroimaging and biomarker evidence of neurodegeneration in asthma.The Journal of allergy and clinical immunology · 2022Article
- Pattern of Altered Magnetization Transfer Rate in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2022Article
- Cognitive dysfunction and cerebral volumetric deficits in individuals with Alzheimer's disease, alcohol use disorder, and dual diagnosis.Psychiatry research. Neuroimaging · 2021Article
- Implicating causal brain imaging endophenotypes in Alzheimer's disease using multivariable IWAS and GWAS summary data.NeuroImage · 2020Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
An increasing number of MRI investigations suggest that patients with Alzheimer's disease (AD) show not only gray matter decreases but also white matter (WM) abnormalities, including WM volume (WMV) deficits and integrity disruption of WM pathways. In this study, we applied multimodal voxel-wise meta-analytical methods to study WMV and fractional anisotropy in AD. Fourteen studies including 723 participants (340 with AD and 383 controls) were involved. The meta-analysis was performed using effect size signed differential mapping. Significant WMV reductions were observed in bilateral inferior temporal gyrus, splenium of corpus callosum, right parahippocampal gyrus, and hippocampus. Decreased fractional anisotropy was identified mainly in left posterior limb of internal capsule, left anterior corona radiata, left thalamus, and left caudate nucleus. Significant decreases of both WMV and fractional anisotropy were found in left caudate nucleus, left superior corona radiata, and right inferior temporal gyrus. Most findings showed to be highly replicable in the jackknife sensitivity analyses. In conclusion, AD patients show widespread WM abnormalities mainly in bilateral structures related to advanced mental and nervous activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.