ReviewJournal of cachexia, sarcopenia and muscle2015
Exercise for cancer cachexia in adults: Executive summary of a Cochrane Collaboration systematic review.
Review in Journal of cachexia, sarcopenia and muscle, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04065984 (BiCyCLE), which is not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BiCyCLE: Neuro-Muscular Electrical Stimulation (NMES) and Its Effect on Changes in Body Composition Following Surgery for Locally Advanced Rectal Cancer - a Single Centre Double Blind Randomised Controlled Phase II Clinical Trial
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Cancer cachexia reduces the efficacy of immune checkpoint inhibitors in cancer patients.Aging · 2024Pooled it
- Guideline
- Exercise for cancer cachexia in adults.The Cochrane database of systematic reviews · 2021Pooled it
- Effects and tolerability of exercise therapy modality on cardiorespiratory fitness in lung cancer: a randomized controlled trial.Journal of cachexia, sarcopenia and muscle · 2021Trial
- Article
- Review
- Cardiovascular and metabolic determinants of quality of life in patients with cancer.ESC heart failure · 2023Article
- Understanding Cancer Cachexia and Its Implications in Upper Gastrointestinal Cancers.Current treatment options in oncology · 2022Review
- Review
- Review
- Cancer Cachexia: Its Mechanism and Clinical Significance.International journal of molecular sciences · 2021Review
- Voluntary exercise does not improve muscular properties or functional capacity during C26-induced cancer cachexia in mice.Journal of muscle research and cell motility · 2021Article
- Diet-related interventions for cancer-associated cachexia.Journal of cancer research and clinical oncology · 2021Review
- A Critical Review of Multimodal Interventions for Cachexia.Advances in nutrition (Bethesda, Md.) · 2021Review
- Determinants of adherence to physical cancer rehabilitation guidelines among cancer patients and cancer centers: a cross-sectional observational study.Journal of cancer survivorship : research and practice · 2021Observational
- Cancer-Associated Muscle Wasting-Candidate Mechanisms and Molecular Pathways.International journal of molecular sciences · 2020Review
- Exercise as a therapy for cancer-induced muscle wasting.Sports medicine and health science · 2020Review
- Repeated eccentric contractions positively regulate muscle oxidative metabolism and protein synthesis during cancer cachexia in mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Selective androgen receptor modulators: the future of androgen therapy?Translational andrology and urology · 2020Review
- Exercise and Physical Activity in Patients with Osteosarcoma and Survivors.Advances in experimental medicine and biology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCancer cachexia is a complex syndrome characterized by an ongoing loss of skeletal muscle mass and progressive functional impairment. A proactive management approach is recommended, including physical exercise to maintain function via modulation of muscle metabolism, insulin sensitivity and levels of inflammation. The review aimed to determine the safety, acceptability and effectiveness of exercise in adults with cancer cachexia. Secondary aims, subject to the data availability, were to compare effectiveness according to the characteristics of the study intervention or population.
methodsWe sought randomised controlled trials (RCTs) in adults meeting international criteria for cancer cachexia, comparing a programme of exercise as a sole or adjunct intervention to usual care or an active control. CENTRAL, MEDLINE, EMBASE, DARE and HTA, ISI Web of Science, LILACS, PEDro, SciVerse SCOPUS, Biosis Previews PreMEDLINE and Open Grey databases were searched up to June 2014. Two authors independently assessed studies for eligibility.
resultsWe screened 3154 separate titles and abstracts, and reviewed 16 full-texts. Corresponding authors were contacted to determine if samples met cachexia staging criteria. Most authors did not explore this concept. No trial met review eligibility criteria. We were unable to perform a meta-analysis to determine any effects from exercise intervention.
conclusionDespite a strong rationale for the use of exercise, there is insufficient evidence to determine safety and effectiveness in patients with cancer cachexia. Findings from ongoing studies are awaited. Assessment of cachexia domains, ideally against international criteria, is required for future trials of exercise and supportive care interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.