ArticleJournal of intercultural ethnopharmacology
Prophylactic effects of humic acid-glucan combination against experimental liver injury.
Article in Journal of intercultural ethnopharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Pharmacological Effects of Humic Substances and the Signaling Mechanisms of Their Implementation.Bulletin of experimental biology and medicine · 2026Review
- Pharmacological Effects of Humic Substances and Their Signaling Mechanisms.Molecules (Basel, Switzerland) · 2025Review
- Humic acid from vermicompost effectively regulates the redox status and mitigates the progression of experimental periodontitis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Humic Acid Derived from Agricultural Biomass Mitigates Alveolar Bone Loss and Modulates Systemic Inflammatory Cytokines in Rats with Periodontitis.Current topics in medicinal chemistry · 2025Article
- Evaluation of the efficacy of humic acids to counteract the toxic effects of aflatoxin B1 in turkey poults.Frontiers in veterinary science · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimDespite intensive research, liver diseases represent a significant health problem and current medicine does not offer a substance able to significantly inhibit the hepatotoxicity leading to various stages of liver disease. Based on our previously published studies showing the protective effects of a glucan-humic acid (HA) combination, we focused on the hypothesis that the combination of these two natural molecules can offer prophylactic protection against experimentally induced hepatotoxicity. MATERIALS AND
methodsLipopolysaccharide, carbon tetrachloride, and ethanol were used to experimentally damage the liver. Levels of aspartate aminotransferase, alanine transaminase, alkaline phosphatase, glutathione, superoxide dismutase, and malondialdehyde, known to correspond to the liver damage, were assayed.
resultsUsing three different hepatotoxins, we found that in all cases, some samples of HA and most of all the glucan-HA combination, offer strong protection against liver damage.
conclusionGlucan-HA combination is a promising agent for use in liver protection.
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Registered trials
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