ArticleJournal of intercultural ethnopharmacology
Effects of Gingko biloba extract on tissue distribution of fluoxetine and venlafaxine in rats.
Article in Journal of intercultural ethnopharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 4 citations in OpenAlex.
- Herbal Medicines and Drugs Interactions: Cytochrome P450 Responsibility.Current medicinal chemistry · 2026Review
- Pharmacokinetic Interactions between Herbal Medicines and Drugs: Their Mechanisms and Clinical Relevance.Life (Basel, Switzerland) · 2020Review
- Effects of Gingko biloba extract on tissue distribution of fluoxetine and venlafaxine in rats.Journal of intercultural ethnopharmacologyArticle
- Natural polyphenols: Influence on membrane transporters.Journal of intercultural ethnopharmacologyReview
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThere are many concerns about the interactions of herbal products with conventional drugs, which are mostly used as multiple drug treatment approach. The present study was designed to evaluate the effect of long-term use of Ginkgo biloba extract (GK) on the absorption and tissue distribution of fluoxetine and venlafaxine. MATERIALS AND
methods46 Wistar rats are utilized and allocated into 8 groups; 2 groups administered the vehicle and saved as control; 4 groups are treated with 100 and 200 mg/kg of GK extract for 30 days; 2 groups are treated with 40 mg/kg verapamil for 10 days. The liver, kidney, and brain distribution of fluoxetine and venlafaxine were evaluated after single oral doses using high performance liquid chromatographic method.
results200 mg/kg GK increases fluoxetine concentrations in all studied organs, while GK 100 mg/kg increases venlafaxine levels in kidney tissue and not affected in the other two organs.
conclusionThirty days treatment with GK (100 mg/kg) increases kidney availability of venlafaxine, while 200 mg GK dose increases fluoxetine availability in the liver, kidney, and brain tissues after single oral doses.
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