ArticleCanine genetics and epidemiology2015
The challenges of pedigree dog health: approaches to combating inherited disease.
Article in Canine genetics and epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Histological analysis of collagen composition in the stifle joint capsule of dogs with congenital patellar luxation and cranial cruciate ligament rupture.Veterinary and animal science · 2026Article
- Sold a pup? Impact of purchasing practices, owner and dog demographics, and puppy early-life experiences on later canine health outcomes in the UK.Animal welfare (South Mimms, England) · 2026Article
- Structural and Histomorphological Evaluation of the Stifle Joint Capsule in Canine Congenital Patellar Luxation and Cranial Cruciate Ligament Rupture.Animals : an open access journal from MDPI · 2025Article
- Health status and disease prevalences in French bulldogs in Germany: insights from a survey-based study.Companion animal health and genetics · 2025Article
- Comparing owner reported and genetic breed identification reveals high concordance in a large cohort from the Dog Aging Project.Scientific reports · 2025Article
- The genetic secrets revealed from canine fetal fluids obtained in mid-pregnancy.Scientific reports · 2025Article
- Genomic Analysis Reveals Inbreeding in an Island Population of Alexander Archipelago Wolves.Evolutionary applications · 2025Article
- PCR-based detection of hereditary mutations inJournal of veterinary science · 2025Article
- Reply to Venturino et al. Comment on "Hladky-Krage, B.; Hoffman, C.L. Expectations versus Reality of Designer Dog Ownership in the United States.Animals : an open access journal from MDPI · 2025Article
- Modern pedigree dogs in the United Kingdom Kennel Club: a journey through shifting population landscapes and demography.Companion animal health and genetics · 2025Article
- Measures of Homozygosity and Relationship to Genetic Diversity in the Bearded Collie Breed.Genes · 2025Article
- Genetic counseling in veterinary medicine: towards an evidence-based definition for the small animal practice.BMC veterinary research · 2025Article
- Domestication constrains the ability of dogs to convey emotions via facial expressions in comparison to their wolf ancestors.Scientific reports · 2024Article
- Longevity of companion dog breeds: those at risk from early death.Scientific reports · 2024Article
- Rising trends in the use of frozen dog sperm: a retrospective study in Belgium and the Netherlands.Frontiers in veterinary science · 2024Article
- Translatability barriers between preclinical and clinical trials of AAV gene therapy in inherited retinal diseases.Vision research · 2023Review
- Expectations versus Reality of Designer Dog Ownership in the United States.Animals : an open access journal from MDPI · 2022Article
- Phenotypic characterization of idiopathic epilepsy and epilepsy of unknown cause in Irish Setters.Frontiers in veterinary science · 2022Article
- Disorder predispositions and protections of Labrador Retrievers in the UK.Scientific reports · 2021Article
- PCR-based genotyping assays to detect germline APC variant associated with hereditary gastrointestinal polyposis in Jack Russell terriers.BMC veterinary research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The issue of inherited disorders and poor health in pedigree dogs has been widely discussed in recent years. With the advent of genome-wide sequencing technologies and the increasing development of new diagnostic DNA disease tests, the full extent and prevalence of inherited disorders in pedigree dogs is now being realized. In this review we discuss the challenges facing pedigree dog breeds: the common pitfalls and problems associated with combating single gene mediated disorders, phenotypic selection on complex disorders, and ways of managing genetic diversity. Breeding strategies incorporating screening schemes have been shown to be successful in significantly reducing the prevalence of an inherited disorder and improving the overall health in certain breeds. However, with 215 breeds officially recognized by the Kennel Club in the United Kingdom and 396 inherited disorders currently identified, many breeds have reached the point at which successfully breeding away from susceptible individuals at a population-wide scale will require new genomic selection strategies in combination with currently available breeding schemes. Whilst DNA-based tests identifying disease causing mutation(s) remain the most informative and effective approach for single gene disorder disease management, they must be used along with current screening schemes, genomic selection, and pedigree information in breeding programs in the effort to maintain genetic diversity while also significantly reducing the number of inherited disorders in pedigree dogs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.