Evidence map›Paper›PMID 26401301›Full record

ArticleBorderline personality disorder and emotion dysregulation2014

Altered connectivity within the salience network during direct eye gaze in PTSD.

Janine Thome, Paul Frewen, Judith K Daniels, Maria Densmore, Ruth A Lanius

Abstract read
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In one paragraph

Article in Borderline personality disorder and emotion dysregulation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Neuroscientific account of Guilt- and Shame-Driven PTSD phenotypes.European journal of psychotraumatology · 2023
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  7. Review
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  9. The Role of the Thalamus in Post-Traumatic Stress Disorder.International journal of molecular sciences · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Janine ThomeDepartment of Psychiatry, Western University, 339 Windermere Rd, PO Box 5339, London, ON N6A 5A5 Canada ; Department of Psychosomatic and Psychotherapeutic Medicine, Central Institute of Mental Health Mannheim, University of Heidelberg, Medical Faculty Mannheim, Heidelberg, Germany.
Paul FrewenDepartment of Psychiatry, Western University, 339 Windermere Rd, PO Box 5339, London, ON N6A 5A5 Canada ; Psychology, Western University, London, ON N6A 5A5 Canada.
Judith K DanielsDepartment of Psychosomatic Medicine and Psychotherapy, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Maria DensmoreDepartment of Psychiatry, Western University, 339 Windermere Rd, PO Box 5339, London, ON N6A 5A5 Canada.
Ruth A LaniusDepartment of Psychiatry, Western University, 339 Windermere Rd, PO Box 5339, London, ON N6A 5A5 Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPosttraumatic stress (PTSD) disorder has been associated with heightened threat sensitivity. Evidence suggests that direct eye gaze leads to sustained activation of the superior colliculus/periaqueductal grey within individuals with PTSD. The present analysis investigated functional connectivity within the salience network (SN) in the same sample as presented in a prior publication during direct versus averted gaze in adults with PTSD related to childhood maltreatment as compared to healthy individuals.

methodsFunctional connectivity within the SN was examined using functional magnetic resonance imaging while participants viewed avatars positioned in direct versus averted gaze relative to the participant in 16 individuals with PTSD related to childhood maltreatment and 16 healthy control subjects. Connectivity within the SN was assessed via Independent Component Analysis (ICA). Associations with symptom severity were explored with multiple regression analyses on individual subject components.

resultsTemporal multiple regression analyses revealed higher connectivity within the SN during direct versus averted gaze which was more pronounced in individuals with PTSD as compared to healthy controls. Compared to controls, individuals with PTSD showed increased integration of the left amygdala and the right insula within the SN. PTSD symptom severity was positively associated with connectivity of the right mid-cingulate cortex within the SN in PTSD subjects only.

conclusionsParticipants with PTSD showed enhanced coupling of the amygdala and the insula within the SN as compared to healthy control subjects during gaze processing. Our results provide evidence for an increased sensitivity of the salience network to direct versus averted gaze in individuals with PTSD related to childhood maltreatment.

Indexed as

AmygdalaChildhood abuseDirect gazefMRI functional connectivity analysisICAInsulaPosttraumatic stress disorderSalience networkTraumatic stress

Identifiers

PMID26401301
PMCPMC4579505

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.