Evidence map›Paper›PMID 26401267›Full record

ArticleF1000Research2015

Evidence against pain specificity in the dorsal posterior insula.

Karen D Davis, M Catherine Bushnell, Gian Domenico Iannetti, Keith St Lawrence, Robert Coghill

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in F1000Research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Article
  3. The fetal pain paradox.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Review
  4. Article
  5. Article
  6. Neocortical circuits in pain and pain relief.Nature reviews. Neuroscience · 2021
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. The search for pain biomarkers in the human brain.Brain : a journal of neurology · 2018
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Attention to pain! A neurocognitive perspective on attentional modulation of pain in neuroimaging studies.Cortex; a journal devoted to the study of the nervous system and behavior · 2017
    Review
  20. Resolving the Brainstem Contributions to Attentional Analgesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Karen D DavisInstitute of Medical Science and Department of Surgery, University of Toronto, Toronto, ON, M5T 2S8, Canada ; Division of Brain Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, Toronto, ON, M5T 2S8, Canada ; Joint Department of Medical Imaging, University Health Network, Toronto, ON, M5T 2S8, Canada.
M Catherine BushnellPain and Integrative Neuroscience Branch, Division of Intramural Research, National Center for Complementary and Integrative Health (NCCIH), National Institutes of Health, Bethesda, MD, 20892-1302, USA.
Gian Domenico IannettiDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, UK.
Keith St LawrenceLawson Health Research Institute, London, ON, N6A 4V2, Canada ; Department of Medical Biophysics, The University of Western Ontario, London, ON, N6A 4V2, Canada.
Robert CoghillDepartment of Anesthesiology, Cincinnati Children's Hospital, Cincinnati, OH, 45229-3026, USA.
Cincinnati Children's Hospital Medical Center · USNational Institutes of Health · USUniversity College London · GBUniversity Health Network · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The search for a "pain centre" in the brain has long eluded neuroscientists.  Although many regions of the brain have been shown to respond to painful stimuli, all of these regions also respond to other types of salient stimuli. In a recent paper, Segerdahl et al. (Nature Neuroscience, 2015)  claims that the dorsal posterior insula (dpIns) is a pain-specific region based on the observation that the magnitude of regional cerebral blood flow (rCBF) fluctuations in the dpIns correlated with the magnitude of evoked pain.  However, such a conclusion is, simply, not justified by the experimental evidence provided.  Here we discuss three major factors that seriously question this claim.

Indexed as

ASLbrain imaginginsulaPain

Identifiers

PMID26401267
PMCPMC4566284
OpenAlexW1906010130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.