Evidence map›Paper›PMID 26401246›Full record

ArticlePulmonary circulation2015

Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute.

Anna R Hemnes, David G Kiely, Barbara A Cockrill, Zeenat Safdar, Victoria J Wilson, Manal Al Hazmi, Ioana R Preston, Mandy R MacLean, Tim Lahm

Open access · bronzeAbstract read
In one paragraph

Article in Pulmonary circulation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 3 pooled it
24.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 3 syntheses or guidelines pooled it, 342 citations in OpenAlex.

  1. Pregnancy conditions and outcomes of Chinese women with mild, moderate and severe pulmonary arterial hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. [Perioperative outcomes and anesthetic management of pregnancy termination in patients with pulmonary hypertension].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Exercise and the lungs: From physiology to pathophysiology - a narrative review.African journal of thoracic and critical care medicine · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Management of Pulmonary Hypertension in Pregnancy.Current heart failure reports · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Observational

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 3 countries.

Anna R HemnesDivision of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, Tennessee, USA.
David G KielySheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals National Health Service (NHS) Foundation Trust, Sheffield, United Kingdom.
Barbara A CockrillDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, and Harvard University Medical School, Boston, Massachusetts, USA.
Zeenat SafdarSection of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, Texas, USA.
Victoria J WilsonDepartment of Obstetrics and Gynaecology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
Manal Al HazmiSection of Pulmonary Diseases, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
Ioana R PrestonPulmonary, Critical Care and Sleep Division, Tufts Medical Center, Boston, Massachusetts, USA.
Mandy R MacLeanInstitute of Cardiovascular and Medical Sciences, College of Medical and Veterinary Science, University of Glasgow, Glasgow, United Kingdom.
Tim LahmDivision of Pulmonary, Allergy, Critical Care, Occupational and Sleep Medicine, Indiana University School of Medicine and Roudebush Veterans Affairs Medical Center, Indianapolis, Indiana, USA.
Baylor College of Medicine · USBrigham and Women's Hospital · USKing Fahad Specialist Hospital · SANational Health Service · GBRichard L. Roudebush VA Medical Center · USSheffield Teaching Hospitals NHS Foundation Trust · GBTufts Medical Center · USUniversity of Glasgow · GBVanderbilt University · US

Funding

British Heart Foundation PG/13/7/29913British Heart Foundation RG/11/7/28916
6 · The paper itself

Abstract

Pregnancy outcomes in patients with pulmonary hypertension remain poor despite advanced therapies. Although consensus guidelines recommend against pregnancy in pulmonary hypertension, it may nonetheless occasionally occur. This guideline document sought to discuss the state of knowledge of pregnancy effects on pulmonary vascular disease and to define usual practice in avoidance of pregnancy and pregnancy management. This guideline is based on systematic review of peer-reviewed, published literature identified with MEDLINE. The strength of the literature was graded, and when it was inadequate to support high-level recommendations, consensus-based recommendations were formed according to prespecified criteria. There was no literature that met standards for high-level recommendations for pregnancy management in pulmonary hypertension. We drafted 38 consensus-based recommendations on pregnancy avoidance and management. Further, we identified the current state of knowledge on the effects of sex hormones during pregnancy on the pulmonary vasculature and right heart and suggested areas for future study. There is currently limited evidence-based knowledge about both the basic molecular effects of sex hormones and pregnancy on the pulmonary vasculature and the best practices in contraception and pregnancy management in pulmonary hypertension. We have drafted 38 consensus-based recommendations to guide clinicians in these challenging topics, but further research is needed in this area to define best practices and improve patient outcomes.

Identifiers

PMID26401246
PMCPMC4556496
OpenAlexW2310788539

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.