ArticleRadiology and oncology2015
Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer.
Article in Radiology and oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 20 citations in OpenAlex.
- Diagnostic value of lesion-to-spinal cord ratio and apparent diffusion coefficient in differentiating benign and malignant pulmonary nodules and masses.Journal of thoracic disease · 2026Article
- MRI analysis of relative tumor enhancement in liver metastases and correlation with immunohistochemical features.Insights into imaging · 2024Article
- A Prospective Observational Study of Diagnostic Reliability of Semiquantitative and Quantitative High b-Value Diffusion-Weighted MRI in Distinguishing between Benign and Malignant Lung Lesions at 3 Tesla.The Indian journal of radiology & imaging · 2024Article
- Pretreatment dual-energy CT for predicting early response to induction chemotherapy and survival in nasopharyngeal carcinoma.European radiology · 2023Article
- Development and validation of novel radiomics-based nomograms for the prediction ofQuantitative imaging in medicine and surgery · 2022Article
- A Noninvasive Assessment of Tumor Proliferation in Lung cancer Patients using Intravoxel Incoherent Motion Magnetic Resonance Imaging.Journal of Cancer · 2021Article
- The associations among quantitative spectral CT parameters, Ki-67 expression levels and EGFR mutation status in NSCLC.Scientific reports · 2020Article
- Thoracic Magnetic Resonance Imaging Applications in Children.The Eurasian journal of medicine · 2020Review
- Associations between apparent diffusion coefficient (ADC) and KI 67 in different tumors: a meta-analysis. Part 2: ADCOncotarget · 2018Article
- Prediction of pancreatic neuroendocrine tumour grade with MR imaging features: added value of diffusion-weighted imaging.European radiology · 2017Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe primary objective of the study was to evaluate the association between the minimum apparent diffusion coefficient (ADCmin) and Ki-67, an index for cellular proliferation, in non-small cell lung cancers. Also, we aimed to assess whether ADCmin values differ between tumour subtypes and tissue sampling method.
methodsThe patients who had diffusion weighted magnetic resonance imaging (DW-MRI) were enrolled retrospectively. The correlation between ADCmin and the Ki-67 index was evaluated.
resultsNinety three patients, with a mean age 65 ± 11 years, with histopathologically proven adenocarcinoma and squamous cell carcinoma of the lungs and had technically successful DW-MRI were included in the study. The numbers of tumour subtypes were 47 for adenocarcinoma and 46 for squamous cell carcinoma. There was a good negative correlation between ADCmin values and the Ki-67 proliferation index (r = -0.837, p < 0.001). The mean ADCmin value was higher and the mean Ki-67 index was lower in adenocarcinomas compared to squamous cell carcinoma (p < 0.0001). There was no statistical difference between tissue sampling methods.
conclusionsBecause ADCmin shows a good but negative correlation with Ki-67 index, it provides an opportunity to evaluate tumours and their aggressiveness and may be helpful in the differentiation of subtypes non-invasively.
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