ArticleChemical senses2015
Immunohistochemical Analysis of Human Vallate Taste Buds.
Article in Chemical senses, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Tyrosine kinase inhibitors affect sweet taste and dysregulate fate selection of specific taste bud cell subtypes via KIT inhibition.Development (Cambridge, England) · 2026Article
- GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine.eLife · 2025Article
- Structural comparisons of human and mouse fungiform taste buds.Chemical senses · 2025Article
- Structural comparisons of human and mouse fungiform taste buds.bioRxiv : the preprint server for biology · 2024Article
- Physiology of the tongue with emphasis on taste transduction.Physiological reviews · 2023Review
- Variability in P2X receptor composition in human taste nerves: implications for treatment of chronic cough.ERJ open research · 2023Article
- Functional expression of TMEM16A in taste bud cells.The Journal of physiology · 2021Article
- The teleost fish, blue gourami Trichopodus trichopterus, distinguishes the taste of chemically similar substances.Scientific reports · 2020Article
- Distribution pattern and molecular signature of cholinergic tuft cells in human gastro-intestinal and pancreatic-biliary tract.Scientific reports · 2019Article
- Obesity is associated with altered gene expression in human tastebuds.International journal of obesity (2005) · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The morphology of the vallate papillae from postmortem human samples was investigated with immunohistochemistry. Microscopically, taste buds were present along the inner wall of the papilla, and in some cases in the outer wall as well. The typical taste cell markers PLCβ2, GNAT3 (gustducin) and the T1R3 receptor stain elongated cells in human taste buds consistent with the Type II cells in rodents. In the human tissue, taste bud cells that stain with Type II cell markers, PLCβ2 and GNAT3, also stain with villin antibody. Two typical immunochemical markers for Type III taste cells in rodents, PGP9.5 and SNAP25, fail to stain any taste bud cells in the human postmortem tissue, although these antibodies do stain numerous nerve fibers throughout the specimen. Car4, another Type III cell marker, reacted with only a few taste cells in our samples. Finally, human vallate papillae have a general network of innervation similar to rodents and antibodies directed against SNAP25, PGP9.5, acetylated tubulin and P2X3 all stain free perigemmal nerve endings as well as intragemmal taste fibers. We conclude that with the exception of certain molecular features of Type III cells, human vallate papillae share the structural, morphological, and molecular features observed in rodents.
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