ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Mortality in Relation to Frailty in Patients Admitted to a Specialized Geriatric Intensive Care Unit.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Methods of Assessing Frailty in the Critically Ill: A Systematic Review of the Current Literature.Gerontology · 2022Pooled it
- Association of Frailty With the Risk of Mortality and Resource Utilization in Elderly Patients in Intensive Care Units: A Meta-Analysis.Frontiers in medicine · 2021Pooled it
- The impact of frailty on intensive care unit outcomes: a systematic review and meta-analysis.Intensive care medicine · 2017Pooled it
- Trial
- Integrating frailty and acute illness severity scoring for risk stratification in acute geriatric care: Review and practical guide.World journal of critical care medicine · 2026Review
- The pictorial fit-frail scale: a novel tool for frailty assessment in critically ill older adults.BMC geriatrics · 2025Article
- Comparative lifespan and healthspan of nonhuman primate species common to biomedical research.GeroScience · 2025Article
- Frailty in Critically Ill Patients with COVID-19: The Lessons Learned.Advances in experimental medicine and biology · 2024Review
- Survival Bias, Non-Lineal Behavioral and Cortico-Limbic Neuropathological Signatures in 3xTg-AD Mice for Alzheimer's Disease from Premorbid to Advanced Stages and Compared to Normal Aging.International journal of molecular sciences · 2023Article
- Clinical Features of SARS-CoV-2 Infection in Older Adults.Clinics in geriatric medicine · 2022Review
- The FRAIL-FIT 30 Study - Factors influencing 30-day mortality in frail patients admitted to ICU: A retrospective observational cohort study.Journal of the Intensive Care Society · 2022Article
- Crosstalk of Alzheimer's disease-phenotype, HPA axis, splenic oxidative stress and frailty in late-stages of dementia, with special concerns on the effects of social isolation: A translational neuroscience approach.Frontiers in aging neuroscience · 2022Article
- How frail is frail? A systematic scoping review and synthesis of high impact studies.BMC geriatrics · 2021Article
- Long-term trends in critical care admissions in Wales*Anaesthesia · 2021Article
- Frailty assessed by administrative tools and mortality in patients with pneumonia admitted to the hospital and ICU in Wales.Scientific reports · 2021Article
- Genotype Load Modulates Amyloid Burden and Anxiety-Like Patterns in Male 3xTg-AD Survivors despite Similar Neuro-Immunoendocrine, Synaptic and Cognitive Impairments.Biomedicines · 2021Article
- Article
- Management of Very Old Patients in Intensive Care Units.Aging and disease · 2021Review
- Longitudinal birth cohort study finds that life-course frailty associates with later-life heart size and function.Scientific reports · 2021Article
- Comparing associations between frailty and mortality in hospitalised older adults with or without COVID-19 infection: a retrospective observational study using electronic health records.Age and ageing · 2021Observational
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn older adults admitted to intensive care units (ICUs), frailty influences prognosis. We examined the relationship between the frailty index (FI) based on deficit accumulation and early and late survival.
methodsOlder patients (≥65 years) admitted to a specialized geriatric ICU at the Liuhuaqiao Hospital, Guangzhou, China between July-December 2011 (n = 155; age 82.7±7.1 y; 87.1% men) were followed for 300 days. The FI was calculated as the proportion present of 52 health deficits. FI performance was compared with that of several prognostic scores.
resultsThe 90-day death rate was 38.7% (n = 60; 27 died within 30 days). The FI score was correlated with the Glasgow Coma Scale, Karnofsky Scale, Palliative Performance Scale, Acute Physiology Score-APACHE II and APACHE IV (r (2) = 0.52 to 0.72, p < 0.001). Patients who died within 30 days had higher mean FI scores (0.41±0.11) than those who survived to 300 days (0.22±0.11; F = 38.91, p < 0.001). Each 1% increase in the FI from the previous level was associated with an 11% increase in the 30-day mortality risk (95% CI: 7%-15%) adjusting for age, sex, and the prognostic scores. The FI discriminated patients who died in 30 days from those who survived with moderately high accuracy (AUC = 0.89±0.03). No one with an FI score >0.46 survived past 90 days.
conclusionICU survival was strongly associated with the level of frailty at admission. An FI based on health deficit accumulation may help improve critical care outcome prediction in older adults.
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