Evidence map›Paper›PMID 26400581›Full record

ArticleNeurology2015

Motion discrimination in dementia with Lewy bodies and Alzheimer disease.

Kelly M Landy, David P Salmon, Douglas Galasko, J Vincent Filoteo, Elena K Festa, William C Heindel, Lawrence A Hansen, Joanne M Hamilton

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Intrinsic capacity in Lewy body dementia: a review.The Journal of frailty & aging · 2025
    Review
  3. Visual dysfunction in dementia with Lewy bodies.Current neurology and neuroscience reports · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Clinical and imaging correlates of amyloid deposition in dementia with Lewy bodies.Movement disorders : official journal of the Movement Disorder Society · 2018
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kelly M LandyFrom the Departments of Neurosciences (K.M.L., D.P.S., D.G., L.A.H., J.M.H.), Psychiatry (J.V.F.), and Pathology (L.A.H.), University of California, San Diego, La Jolla; the Departments of Neurology (D.G.) and Psychology Services (J.V.F.), Veterans Affairs San Diego Healthcare System, La Jolla, CA; and the Department of Cognitive, Linguistic and Psychological Sciences (E.K.F., W.C.H.), Brown University, Providence, RI.
David P SalmonFrom the Departments of Neurosciences (K.M.L., D.P.S., D.G., L.A.H., J.M.H.), Psychiatry (J.V.F.), and Pathology (L.A.H.), University of California, San Diego, La Jolla; the Departments of Neurology (D.G.) and Psychology Services (J.V.F.), Veterans Affairs San Diego Healthcare System, La Jolla, CA; and the Department of Cognitive, Linguistic and Psychological Sciences (E.K.F., W.C.H.), Brown University, Providence, RI. dsalmon@ucsd.edu.
Douglas GalaskoFrom the Departments of Neurosciences (K.M.L., D.P.S., D.G., L.A.H., J.M.H.), Psychiatry (J.V.F.), and Pathology (L.A.H.), University of California, San Diego, La Jolla; the Departments of Neurology (D.G.) and Psychology Services (J.V.F.), Veterans Affairs San Diego Healthcare System, La Jolla, CA; and the Department of Cognitive, Linguistic and Psychological Sciences (E.K.F., W.C.H.), Brown University, Providence, RI.
J Vincent FiloteoFrom the Departments of Neurosciences (K.M.L., D.P.S., D.G., L.A.H., J.M.H.), Psychiatry (J.V.F.), and Pathology (L.A.H.), University of California, San Diego, La Jolla; the Departments of Neurology (D.G.) and Psychology Services (J.V.F.), Veterans Affairs San Diego Healthcare System, La Jolla, CA; and the Department of Cognitive, Linguistic and Psychological Sciences (E.K.F., W.C.H.), Brown University, Providence, RI.
Elena K FestaFrom the Departments of Neurosciences (K.M.L., D.P.S., D.G., L.A.H., J.M.H.), Psychiatry (J.V.F.), and Pathology (L.A.H.), University of California, San Diego, La Jolla; the Departments of Neurology (D.G.) and Psychology Services (J.V.F.), Veterans Affairs San Diego Healthcare System, La Jolla, CA; and the Department of Cognitive, Linguistic and Psychological Sciences (E.K.F., W.C.H.), Brown University, Providence, RI.
William C HeindelFrom the Departments of Neurosciences (K.M.L., D.P.S., D.G., L.A.H., J.M.H.), Psychiatry (J.V.F.), and Pathology (L.A.H.), University of California, San Diego, La Jolla; the Departments of Neurology (D.G.) and Psychology Services (J.V.F.), Veterans Affairs San Diego Healthcare System, La Jolla, CA; and the Department of Cognitive, Linguistic and Psychological Sciences (E.K.F., W.C.H.), Brown University, Providence, RI.
Lawrence A HansenFrom the Departments of Neurosciences (K.M.L., D.P.S., D.G., L.A.H., J.M.H.), Psychiatry (J.V.F.), and Pathology (L.A.H.), University of California, San Diego, La Jolla; the Departments of Neurology (D.G.) and Psychology Services (J.V.F.), Veterans Affairs San Diego Healthcare System, La Jolla, CA; and the Department of Cognitive, Linguistic and Psychological Sciences (E.K.F., W.C.H.), Brown University, Providence, RI.
Joanne M HamiltonFrom the Departments of Neurosciences (K.M.L., D.P.S., D.G., L.A.H., J.M.H.), Psychiatry (J.V.F.), and Pathology (L.A.H.), University of California, San Diego, La Jolla; the Departments of Neurology (D.G.) and Psychology Services (J.V.F.), Veterans Affairs San Diego Healthcare System, La Jolla, CA; and the Department of Cognitive, Linguistic and Psychological Sciences (E.K.F., W.C.H.), Brown University, Providence, RI.
VA San Diego Healthcare System · US

Funding

VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALASKO, DOUGLAS R · 1985 to 2018
$55.4M
COGNITIVE STUDIES OF THE LEWY BODY VARIANT OF ADR01AG012963 · NIA · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI SALMON, DAVID P · 1994 to 2005
$1.0M
Visual Cognition in Dementia with Lewy BodiesR01NS049298 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, JOANNE M · 2007 to 2010
$543k
NIA NIH HHS AG05131NIA NIH HHS AG12963NIA NIH HHS P50 AG005131NINDS NIH HHS NS049298NINDS NIH HHS R01 NS049298
6 · The paper itself

Abstract

objectiveVisual processing abilities of patients with dementia with Lewy bodies (DLB) or Alzheimer disease (AD) dementia were assessed psychophysically using a simple horizontal motion discrimination task that engages the dorsal visual processing stream.

methodsParticipants included patients with mild dementia with DLB, AD dementia or Parkinson disease (PD) with dementia (PDD), without dementia with PD, and normal controls. Participants indicated the left or right direction of coherently moving dots that were embedded within dynamic visual noise provided by randomly moving dots. The proportion of coherently moving dots was increased or decreased across trials to determine a threshold at which participants could correctly indicate their direction with greater than 80% accuracy.

resultsMotion discrimination thresholds of patients with DLB and PDD were comparable and significantly higher (i.e., worse) than those of patients with AD dementia. The thresholds of patients with AD dementia and patients with PD were normal. These results were confirmed in subgroups of patients with DLB/PDD and AD dementia with autopsy-confirmed disease. A motion discrimination threshold greater than 0.23 distinguished between DLB/PDD and AD dementia with 67% sensitivity and 85% specificity.

conclusionsDifferential deficits in detecting direction of simple horizontal motion suggest that dorsal processing stream dysfunction is greater in DLB and PDD than in AD dementia. Therefore, impaired performance on simple visual motion discrimination tasks that specifically engage occipitoparietal brain regions suggests the presence of Lewy body pathology.

Indexed as

Discrimination LearningMotion PerceptionNeuropsychological TestsAgedAged, 80 and overAlzheimer DiseaseFemaleHumansLewy Body DiseaseMalePhotic Stimulation

Identifiers

PMID26400581
PMCPMC4626245
OpenAlexW2194869761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.