ArticleBMC biology2015
Using mathematical models to understand metabolism, genes, and disease.
Article in BMC biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Automated Classification of Homeostasis Structure in Input-Output Networks.Bulletin of mathematical biology · 2026Article
- Homeostasis in networks with multiple inputs.Journal of mathematical biology · 2024Article
- Modeling the effects of strigolactone levels on maize root system architecture.Frontiers in plant science · 2023Article
- Analysis of Hepatic Lipid Metabolism Model: Simulation and Non-Stationary Global Sensitivity Analysis.Nutrients · 2022Article
- Deciphering signal transduction networks in the liver by mechanistic mathematical modelling.The Biochemical journal · 2022Article
- The structure of infinitesimal homeostasis in input-output networks.Journal of mathematical biology · 2021Article
- Overcoming the Challenges to Enhancing Experimental Plant Biology With Computational Modeling.Frontiers in plant science · 2021Review
- A Mathematical Model of the Dynamics of Cytokine Expression and Human Immune Cell Activation in Response to the PathogenFrontiers in cellular and infection microbiology · 2021Article
- Infinitesimal homeostasis in three-node input-output networks.Journal of mathematical biology · 2020Article
- Sex differences in hepatic one-carbon metabolism.BMC systems biology · 2018Article
- Assigning function to natural allelic variation via dynamic modeling of gene network induction.Molecular systems biology · 2018Article
- Heterosis Is a Systemic Property Emerging From Non-linear Genotype-Phenotype Relationships: Evidence FromFrontiers in genetics · 2018Article
- Analysis of Homeostatic Mechanisms in Biochemical Networks.Bulletin of mathematical biology · 2017Article
- Mathematical Models for Immunology: Current State of the Art and Future Research Directions.Bulletin of mathematical biology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mathematical models are a useful tool for investigating a large number of questions in metabolism, genetics, and gene-environment interactions. A model based on the underlying biology and biochemistry is a platform for in silico biological experimentation that can reveal the causal chain of events that connect variation in one quantity to variation in another. We discuss how we construct such models, how we have used them to investigate homeostatic mechanisms, gene-environment interactions, and genotype-phenotype mapping, and how they can be used in precision and personalized medicine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.