Evidence map›Paper›PMID 26400379›Full record

ArticlePublic health action2015

Impact of mycobacterial culture among HIV-infected adults with presumed TB in Uganda: a prospective cohort study.

F C Semitala, L H Chaisson, S den Boon, N Walter, A Cattamanchi, M Awor, J Katende, L Huang, M Joloba, H Albert and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Public health action, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

F C SemitalaDepartment of Medicine, Mulago Hospital, Makerere University College of Health Sciences, Kampala, Uganda ; Makerere University Joint AIDS Program, Kampala, Uganda.
L H ChaissonDivision of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA.
S den BoonMakerere University-University of California San Francisco Research Collaboration, Kampala, Uganda.
N WalterDivision of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Denver, Colorado, USA.
A CattamanchiDivision of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA ; Makerere University-University of California San Francisco Research Collaboration, Kampala, Uganda ; Curry International Tuberculosis Center, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA.
M AworMakerere University-University of California San Francisco Research Collaboration, Kampala, Uganda.
J KatendeMakerere University Joint AIDS Program, Kampala, Uganda.
L HuangDivision of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA ; HIV/AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA.
M JolobaDepartment of Microbiology, Makerere University School of Biomedical Sciences, Kampala, Uganda.
H AlbertFoundation for Innovative New Diagnostics, Kampala, Uganda.
M R KamyaDepartment of Medicine, Mulago Hospital, Makerere University College of Health Sciences, Kampala, Uganda ; Makerere University Joint AIDS Program, Kampala, Uganda.
J L DavisDivision of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA ; Makerere University-University of California San Francisco Research Collaboration, Kampala, Uganda ; Curry International Tuberculosis Center, San Francisco General Hospital, University of California San Francisco, San Francisco, California, USA.

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
International HIV-associated Opportunistic Pneumonias (IHOP) StudyR01HL090335 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2007 to 2011
$4.0M
Patient-Oriented Research and Mentoring in PneumocystisK24HL087713 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, LAURENCE · 2006 to 2018
$1.8M
Immunodiagnosis of Active Tuberculosis in HIV-infected PatientsK23HL094141 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CATTAMANCHI, ADITHYA · 2009 to 2013
$760k
Oral Wash for Nucleic Acid Diagnosis and Prognosis of TB in HIV-Infected UgandansK23AI080147 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DAVIS, JOHN LUCIAN · 2008 to 2012
$711k
NHLBI NIH HHS K23 HL094141NHLBI NIH HHS K24 HL087713NHLBI NIH HHS R01 HL090335NIAID NIH HHS K23 AI080147
6 · The paper itself

Abstract

backgroundImplementation of new tuberculosis (TB) diagnostic strategies in resource-constrained settings is challenging. We measured the impact of solid and liquid mycobacterial cultures on treatment practices for patients undergoing TB evaluation in Kampala, Uganda.

methodsWe enrolled consecutive smear-negative, human immunodeficiency virus positive adults with cough of ⩾2 weeks from September 2009 to April 2010. Laboratory technicians performed mycobacterial cultures on solid and liquid media. We compared empiric treatment decisions with solid and liquid culture in terms of diagnostic yield and time to results, and assessed impact on patient management.

resultsOf 200 patients enrolled, 26 (13%) had culture-confirmed TB: 22 (85%) on solid culture alone, 2 (8%) on liquid culture alone, and 2 (8%) on both solid and liquid culture. Thirty-four patients received empiric anti-tuberculosis treatment, but only 10 (29%) were culture-positive. Median time to a positive result on solid culture was 92 days (interquartile range [IQR] 69-148) compared to 106 days (IQR 66-157) for liquid culture. No patients initiated treatment following a positive result on liquid culture.

conclusionThe introduction of mycobacterial culture did not influence care for patients undergoing evaluation for TB in Kampala, Uganda. Attention to contextual factors surrounding implementation is needed to ensure the effective introduction of new testing strategies in low-income countries.

Indexed as

diagnosticsimplementation scienceliquid culture

Identifiers

PMID26400379
PMCPMC4487479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.