ArticleJournal of neurophysiology2015
Optogenetic study of the projections from the bed nucleus of the stria terminalis to the central amygdala.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 65 citations in OpenAlex.
- Serotonergic modulation of the BNST-CeA pathway reveals sex differences in fear learning.Nature neuroscience · 2025Article
- Acute and chronic alcohol modulation of extended amygdala calcium dynamics.Alcohol (Fayetteville, N.Y.) · 2024Article
- Acute and chronic alcohol modulation of extended amygdala calcium dynamics.bioRxiv : the preprint server for biology · 2023Article
- Regulation of alcohol drinking by ventral striatum and extended amygdala circuitry.Neuropharmacology · 2022Review
- Central nucleus of the amygdala projections onto the nucleus accumbens core regulate binge-like alcohol drinking in a CRF-dependent manner.Neuropharmacology · 2022Article
- Sex-specific plasticity in CRF regulation of inhibitory control in central amygdala CRF1 neurons after chronic voluntary alcohol drinking.Addiction biology · 2022Article
- Mitophagy in the basolateral amygdala mediates increased anxiety induced by aversive social experience.Neuron · 2021Article
- CRHMolecular psychiatry · 2021Article
- Optogenetic study of central medial and paraventricular thalamic projections to the basolateral amygdala.Journal of neurophysiology · 2021Article
- Oxytocin excites BNST interneurons and inhibits BNST output neurons to the central amygdala.Neuropharmacology · 2021Article
- Behavioral and brain mechanisms mediating conditioned flight behavior in rats.Scientific reports · 2021Article
- Extended amygdala circuits are differentially activated by context fear conditioning in male and female rats.Neurobiology of learning and memory · 2021Article
- Effective connectivity between bed nucleus of the stria terminalis and amygdala: Reproducibility and relation to anxiety.Human brain mapping · 2021Article
- Limbic Neuropeptidergic Modulators of Emotion and Their Therapeutic Potential for Anxiety and Post-Traumatic Stress Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Mental Resilience and Coping With Stress: A Comprehensive, Multi-level Model of Cognitive Processing, Decision Making, and Behavior.Frontiers in behavioral neuroscience · 2021Article
- Transcriptional Profiling of Primate Central Nucleus of the Amygdala Neurons to Understand the Molecular Underpinnings of Early-Life Anxious Temperament.Biological psychiatry · 2020Article
- Phasic signaling in the bed nucleus of the stria terminalis during fear learning predicts within- and across-session cued fear expression.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Examining the contribution of histone modification to sex differences in learning and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- Resting-state fMRI effective connectivity between the bed nucleus of the stria terminalis and amygdala nuclei.Human brain mapping · 2019Article
- Magnetic Entropy as a Proposed Gating Mechanism for Magnetogenetic Ion Channels.Biophysical journal · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
It has been proposed that the central amygdala (CeA), particularly its medial sector (CeM), generates brief fear responses to discrete conditioned cues, whereas the bed nucleus of the stria terminalis (BNST) promotes long-lasting, anxiety-like states in response to more diffuse contingencies. Although it is believed that BNST-CeA interactions determine the transition between short- and long-duration responses, the nature of these interactions remains unknown. To shed light on this question, we used a double viral strategy to drive the expression of channelrhodopsin (ChR2) in BNST cells that project to CeA. Next, using patch-clamp recordings in vitro, we investigated the connectivity of infected cells to noninfected cells in BNST and compared the influence of BNST axons on neurons in the medial and lateral (CeL) parts of CeA. CeA-projecting BNST cells were concentrated in the anterolateral (AL) and anteroventral (AV) sectors of BNST. Dense plexuses of BNST axons were observed throughout CeA. In CeA and BNST, light-evoked excitatory postsynaptic potentials accounted for a minority of responses (0-9% of tested cells); inhibition prevailed. The incidence of inhibitory responses was higher in CeM than in CeL (66% and 43% of tested cells, respectively). Within BNST, the connections from CeA-projecting to non-CeA-targeting cells varied as a function of the BNST sector: 50% vs. 9% of tested cells exhibited light-evoked responses in BNST-AL vs. BNST-AV, respectively. Overall, these results suggest that via its projection to CeA, BNST exerts an inhibitory influence over cued fear and that BNST neurons projecting to CeA form contrasting connections in different BNST subnuclei.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.