ArticleJournal of neurophysiology2015
Characterizing and modeling the intrinsic light response of rat ganglion-cell photoreceptors.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Circadian phase resetting by a single short-duration light exposure.JCI insight · 2017Trial
- Advantages of human opsins in optogenetic visual restoration.Frontiers in neuroscience · 2025Review
- Retinal inputs that drive optomotor responses of mice under mesopic conditions.IBRO neuroscience reports · 2024Article
- Modeling the Effects of Napping and Non-napping Patterns of Light Exposure on the Human Circadian Oscillator.Journal of biological rhythms · 2023Article
- S-Cone Photoreceptors Regulate Daily Rhythms and Light-Induced Arousal/Wakefulness in Diurnal Grass Rats (Journal of biological rhythms · 2023Article
- A Phenomenological Mouse Circadian Pacemaker Model.Journal of biological rhythms · 2022Article
- M1-Type, but Not M4-Type, Melanopsin Ganglion Cells Are Physiologically Tuned to the Central Circadian Clock.Frontiers in neuroscience · 2021Article
- Circadian Responses to Light-Flash Exposure: Conceptualization and New Data Guiding Future Directions.Frontiers in neurology · 2021Article
- The Roles of Rods, Cones, and Melanopsin in Photoresponses of M4 Intrinsically Photosensitive Retinal Ganglion Cells (ipRGCs) and Optokinetic Visual Behavior.Frontiers in cellular neuroscience · 2018Article
- Article
- LED Lights With Hidden Intensity-Modulated Blue Channels Aiming for Enhanced Subconscious Visual Responses.IEEE photonics journal · 2017Article
- A Novel Role for the Visual Retinoid Cycle in Melanopsin Chromophore Regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Intrinsically photosensitive retinal ganglion cells (ipRGCs) mediate both image-forming vision and non-image-forming visual responses such as pupillary constriction and circadian photoentrainment. Five types of ipRGCs, named M1-M5, have been discovered in rodents. To further investigate their photoresponse properties, we made multielectrode array spike recordings from rat ipRGCs, classified them into M1, M2/M4, and M3/M5 clusters, and measured their intrinsic, melanopsin-based responses to single and flickering light pulses. Results showed that ipRGC spiking can track flickers up to ∼0.2 Hz in frequency and that flicker intervals between 5 and 14 s evoke the most spikes. We also learned that melanopsin's integration time is intensity and cluster dependent. Using these data, we constructed a mathematical model for each cluster's intrinsic photoresponse. We found that the data for the M1 cluster are best fit by a model that assumes a large photoresponse, causing the cell to enter depolarization block. Our models also led us to hypothesize that the M2/M4 and M3/M5 clusters experience comparable photoexcitation but that the M3/M5 cascade decays significantly faster than the M2/M4 cascade, resulting in different response waveforms between these clusters. These mathematical models will help predict how each ipRGC cluster might respond to stimuli of any waveform and could inform the invention of lighting technologies that promote health through melanopsin stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.