Trial reportAmerican journal of physiology. Regulatory, integrative and comparative physiology2015
Sympathetic neural reactivity to mental stress in humans: test-retest reproducibility.
Trial report in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Effects of acute ketone monoester ingestion on heart rate, blood pressure and muscle sympathetic nerve activity at rest and stress in healthy adults.Physiological reports · 2025Trial
- Binge Alcohol Consumption Elevates Sympathetic Transduction to Blood Pressure: A Randomized Controlled Trial.Hypertension (Dallas, Tex. : 1979) · 2024Trial
- Acute effects of device-guided slow breathing on sympathetic nerve activity and baroreflex sensitivity in posttraumatic stress disorder.American journal of physiology. Heart and circulatory physiology · 2018Trial
- Between-visit reproducibility of cerebrovascular and cardiovascular reactivity during the cold pressor test.American journal of physiology. Heart and circulatory physiology · 2026Article
- Continuous blood pressure variability within young, healthy adults: a test-retest study to assess relative and absolute reliability.American journal of physiology. Heart and circulatory physiology · 2026Article
- Habitual sleep duration is associated with heightened muscle sympathetic nerve activation and blood pressure reactivity in response to the cold pressor test.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Beneficial Effects of Cocoa Flavanols on Microvascular Responses in Young Men May Be Dependent on Ethnicity and Lifestyle.Nutrients · 2024Article
- Neurovascular and hemodynamic responses to mental stress and exercise in severe COVID-19 survivors.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Blood pressure and muscle sympathetic nerve activity are associated with trait anxiety in humans.American journal of physiology. Heart and circulatory physiology · 2023Article
- Greater resting muscle sympathetic nerve activity reduces cold pressor autonomic reactivity in older women, but not older men.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Sympathetic neural reactivity to the Trier social stress test.The Journal of physiology · 2022Article
- Recruiting "clean" chronic insomnia participants: the unicorn of sleep research.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Sympathetic neural responses to sleep disorders and insufficiencies.American journal of physiology. Heart and circulatory physiology · 2022Review
- Aortic haemodynamics: the effects of habitual endurance exercise, age and muscle sympathetic vasomotor outflow in healthy men.European journal of applied physiology · 2022Article
- Consistency of hemodynamic and autonomic mechanisms underlying post-exercise hypotension.Journal of human hypertension · 2021Article
- Reproducibility of the neurocardiovascular responses to common laboratory-based sympathoexcitatory stimuli in young adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Impact of age and sex on neural cardiovascular responsiveness to cold pressor test in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Microneurography and sympathetic nerve activity: a decade-by-decade journey across 50 years.Journal of neurophysiology · 2019Review
- Elevated resting blood pressure augments autonomic imbalance in posttraumatic stress disorder.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Heritability and genetic correlations of heart rate variability at rest and during stress in the Oman Family Study.Journal of hypertension · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mental stress consistently increases arterial blood pressure, but this reliable pressor response is often associated with highly variable muscle sympathetic nerve activity (MSNA) responsiveness between individuals. Although MSNA has been shown to be reproducible within individuals at rest and during the cold pressor test (CPT), intraindividual reproducibility of MSNA responsiveness to mental stress has not been adequately explored. The purpose of this study was to examine MSNA reactivity to mental stress across three experimental sessions. Sixteen men and women (age 21 ± 1 yr) performed two experimental sessions within a single laboratory visit and a third experimental session 1 mo later. Each experimental session consisted of a mental stress trial via mental arithmetic and a CPT trial. Blood pressure, heart rate (HR), and MSNA were measured, and the consistencies of these variables were determined using intraclass correlation (Cronbach's α coefficient). MSNA, mean arterial pressure (MAP), and HR were highly reproducible across the baselines preceding mental stress (Cronbach's α ≥ 0.816, P ≤ 0.001) and CPT (Cronbach's α ≥ 0.782, P ≤ 0.001). Across the three mental stress trials, changes in MSNA (Cronbach's α = 0.875; P = 0.001), MAP (Cronbach's α = 0.749; P < 0.001), and HR (Cronbach's α = 0.919; P < 0.001) were reproducible. During CPT, changes in MSNA (Cronbach's α = 0.805; P = 0.008), MAP (Cronbach's α = 0.878; P < 0.001), and HR (Cronbach's α = 0.927; P < 0.001) remained consistent across the three sessions. In conclusion, our findings demonstrate that MSNA reactivity to mental stress is consistent within a single laboratory visit and across laboratory sessions conducted on separate days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.