ArticleAnnals of biomedical engineering2016
Sonic Estimation of Elasticity via Resonance: A New Method of Assessing Hemostasis.
Article in Annals of biomedical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Efficacy of sonorheometry point of the care device in determining low fibrinogen levels in pregnant blood: an invitro dilution and reconstitution study.Journal of clinical monitoring and computing · 2022Trial
- Baseline values for QuantraBMC pregnancy and childbirth · 2025Observational
- Article
- Multicenter evaluation of the Quantra with the QStat Cartridge in adult trauma patients.Trauma surgery & acute care open · 2025Article
- Article
- Sonorheometry Device Thresholds in Liver Transplantation: An Observational Retrospective Study.Journal of clinical medicine · 2024Article
- Relationship between sonorheometry parameters and laboratory values in a critical care setting in Italy: a retrospective cohort study.Journal of trauma and injury · 2023Article
- Retrospective study assessing outcomes in cardiac surgery after implementation of Quantra.Journal of cardiothoracic surgery · 2023Article
- Questions about COVID-19 associated coagulopathy: possible answers from the viscoelastic tests.Journal of clinical monitoring and computing · 2022Review
- Comparison of the resonance sonorheometry based Quantra® system with rotational thromboelastometry ROTEM® sigma in cardiac surgery - a prospective observational study.BMC anesthesiology · 2021Observational
- Resonant acoustic rheometry for non-contact characterization of viscoelastic biomaterials.Biomaterials · 2021Article
- Viscoelastic Haemostatic Assays in Cardiovascular Critical Care.Cardiac failure review · 2020Review
- Hemostatic Testing in Critically Ill Infants and Children.Frontiers in pediatrics · 2020Review
- Comparison of Coagulation Parameters in Arterial and Venous Blood in Cardiac Surgery Measured Using the Quantra System.Journal of cardiothoracic and vascular anesthesia · 2019Observational
- Production of acoustic radiation force using ultrasound: methods and applications.Expert review of medical devices · 2018Review
- A Novel Device for the Evaluation of Hemostatic Function in Critical Care Settings.Anesthesia and analgesia · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Uncontrolled bleeding threatens patients undergoing major surgery and in care for traumatic injury. This paper describes a novel method of diagnosing coagulation dysfunction by repeatedly measuring the shear modulus of a blood sample as it clots in vitro. Each measurement applies a high-energy ultrasound pulse to induce a shear wave within a rigid walled chamber, and then uses low energy ultrasound pulses to measure displacements associated with the resonance of that shear wave. Measured displacements are correlated with predictions from finite difference time domain models, with the best fit corresponding to the modulus estimate. In our current implementation each measurement requires 62.4 ms. Experimental data was analyzed using a fixed-viscosity algorithm and a free-viscosity algorithm. In experiments utilizing human blood induced to clot by exposure to kaolin, the free-viscosity algorithm quantified the shear modulus of formed clots with a worst-case precision of 2.5%. Precision was improved to 1.8% by utilizing the fixed-viscosity algorithm. Repeated measurements showed a smooth evolution from liquid blood to a firm clot with a shear modulus between 1.4 and 3.3 kPa. These results show the promise of this technique for rapid, point of care assessment of coagulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.