Brain-based etiology of weight regulation.

Kyle S Burger, Grace E Shearrer, Abigail J Sanders

Abstract readReview

In one paragraph

Review in Current diabetes reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

A randomized controlled trial investigating the effect of liraglutide on self-reported liking and neural responses to food stimuli in participants with obesity.International journal of obesity (2005) · 2023
Trial

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kyle S BurgerDepartment of Nutrition, University of North Carolina at Chapel Hill, 2204 McGravran-Greenberg Hall, CB 7461, Chapel Hill, NC, 27599, USA. kyle_burger@unc.edu.

Grace E ShearrerDepartment of Nutrition, University of Texas, Austin, TX, USA.

Abigail J SandersDepartment of Nutrition, University of North Carolina at Chapel Hill, 2204 McGravran-Greenberg Hall, CB 7461, Chapel Hill, NC, 27599, USA.

Funding

NUTRITION TRAINING PROGRAMT32DK007686 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BECK, MELINDA A., MAYER-DAVIS, ELIZABETH J · 1992 to 2022

$4.3M

NIDDK NIH HHS T32 DK007686NIDDK NIH HHS T32DK007686

6 · The paper itself

Abstract

Caloric intake and energy balance are highly regulated to maintain metabolic homeostasis and weight. However, hedonic-motivated food intake, in particular consumption of highly rewarding foods, may act to override hemostatic signaling and contribute to overconsumption, weight gain, and obesity. Here, we review human neuroimaging literature that has delivered valuable insight into the neural correlates of hedonic-motivated ingestive behavior, weight gain, weight loss, and metabolic status. Our primary focus is the brain regions that are thought to encode aspects of food hedonics, gustatory and somatosensory processing, and executive functioning. Further, we discuss the variability of regional brain response as a function of obesity, weight gain, behavioral and surgical weight loss, as well as in type 2 diabetes.

Indexed as

AnimalsBrainDiabetes Mellitus, Type 2EatingFeeding BehaviorHumansObesityWeight GainFood intakeFunctional MRIHedonically motivated food intakeIngestive behaviorObesityReward

Identifiers

PMID26399983

DOI10.1007/s11892-015-0667-5

PMCPMC9257698

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.