ArticleThe American journal of clinical nutrition2015
Tracking of 25-hydroxyvitamin D status during pregnancy: the importance of vitamin D supplementation.
Article in The American journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Maternal and Fetal Genetic Variation in Vitamin D Metabolism and Umbilical Cord Blood 25-Hydroxyvitamin D.The Journal of clinical endocrinology and metabolism · 2022Pooled it
- Determinants and Measurement of Neonatal Vitamin D: Overestimation of 25(OH)D in Cord Blood Using CLIA Assay Technology.The Journal of clinical endocrinology and metabolism · 2020Trial
- Response to Antenatal Cholecalciferol Supplementation Is Associated With Common Vitamin D-Related Genetic Variants.The Journal of clinical endocrinology and metabolism · 2017Trial
- Determinants of the Maternal 25-Hydroxyvitamin D Response to Vitamin D Supplementation During Pregnancy.The Journal of clinical endocrinology and metabolism · 2016Trial
- Article
- Prenatal and child vitamin D levels and allergy and asthma in childhood.Pediatric research · 2023Article
- Prenatal Vitamin D Levels Influence Growth and Body Composition until 11 Years in Boys.Nutrients · 2023Article
- Vitamin D Metabolites: Analytical Challenges and Clinical Relevance.Calcified tissue international · 2023Review
- Early pregnancy vitamin D status is associated with blood pressure in children: an Odense Child Cohort study.The American journal of clinical nutrition · 2022Observational
- Effects of vitamin D on bone density in healthy children: A systematic review.Journal of family medicine and primary care · 2022Review
- Prenatal Vitamin D Levels in Maternal Sera and Offspring Specific Learning Disorders.Nutrients · 2021Article
- Tracking of serum 25-hydroxyvitamin D during 21 years.European journal of clinical nutrition · 2021Article
- Vitamin D Status and Its Determinants in Mexican Pregnant Women from a Rural and an Urban Area: A Comparative Study.International journal of environmental research and public health · 2021Article
- Genetic Link Determining the Maternal-Fetal Circulation of Vitamin D.Frontiers in genetics · 2021Article
- The importance of maternal pregnancy vitamin D for offspring bone health: learnings from the MAVIDOS trial.Therapeutic advances in musculoskeletal disease · 2021Review
- Article
- Vitamin D Deficiency in Mexican Pregnant Women: Is Supplementation with ≤400 IU/day Enough?Nutrients · 2020Article
- Greater risk of severe COVID-19 in Black, Asian and Minority Ethnic populations is not explained by cardiometabolic, socioeconomic or behavioural factors, or by 25(OH)-vitamin D status: study of 1326 cases from the UK Biobank.Journal of public health (Oxford, England) · 2020Article
- Neonatal Vitamin D Status and Risk of Asthma in Childhood: Results from the D-Tect Study.Nutrients · 2020Article
- Vitamin D Status Increases During Pregnancy and in Response to Vitamin D Supplementation in Rural Gambian Women.The Journal of nutrition · 2020Article
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9 authors.
Funding
Abstract
backgroundThe role of maternal 25-hydroxyvitamin D [25(OH)D] in fetal development is uncertain, and findings of observational studies have been inconsistent. Most studies have assessed 25(OH)D only one time during pregnancy, but to our knowledge, the tracking of an individual's 25(OH)D during pregnancy has not been assessed previously.
objectiveWe determined the tracking of serum 25(OH)D from early to late pregnancy and factors that influence this.
designThe Southampton Women's Survey is a prospective mother-offspring birth-cohort study. Lifestyle, diet, and 25(OH)D status were assessed at 11 and 34 wk of gestation. A Fourier transformation was used to model the seasonal variation in 25(OH)D for early and late pregnancy separately, and the difference between the measured and seasonally modeled 25(OH)D was calculated to generate a season-corrected 25(OH)D. Tracking was assessed with the use of the Pearson correlation coefficient, and multivariate linear regression was used to determine factors associated with the change in season-corrected 25(OH)D.
resultsA total of 1753 women had 25(OH)D measured in both early and late pregnancy. There was a moderate correlation between season-corrected 25(OH)D measurements at 11 and 34 wk of gestation (r = 0.53, P < 0.0001; n = 1753). Vitamin D supplementation was the strongest predictor of tracking; in comparison with women who never used supplements, the discontinuation of supplementation after 11 wk was associated with a reduction in season-corrected 25(OH)D (β = -7.3 nmol/L; P < 0.001), whereas the commencement (β = 12.6 nmol/L; P < 0.001) or continuation (β = 6.6 nmol/L; P < 0.001) of supplementation was associated with increases in season-corrected 25(OH)D. Higher pregnancy weight gain was associated with a reduction in season-corrected 25(OH)D (β = -0.4 nmol · L(-1) · kg(-1); P = 0.015), whereas greater physical activity (β = 0.4 nmol/L per h/wk; P = 0.011) was associated with increases.
conclusionsThere is a moderate tracking of 25(OH)D status through pregnancy; factors such as vitamin D supplementation, weight gain, and physical activity are associated with changes in season-corrected 25(OH)D from early to late gestation. These findings have implications for study designs and analyses and approaches to intervention studies and clinical care.
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