ReviewActa veterinaria Scandinavica2015
Virus-induced congenital malformations in cattle.
Review in Acta veterinaria Scandinavica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 94 citations in OpenAlex.
- Role of vimentin in inhibiting akabane virus replication and its preliminary exploration of mechanisms involving autophagy and apoptosis.BMC veterinary research · 2026Article
- An inherited SLC25A12-related recessive form of congenital porencephaly in Limousin cattle.Genetics, selection, evolution : GSE · 2026Article
- Risk Factors for Tail Alterations on German Dairy Farms.Animals : an open access journal from MDPI · 2026Article
- First Complete Morphological Description of Schistosoma Reflexum in a Llama.Veterinary medicine and science · 2026Article
- A CACNA2D2-Related Recessive Form of Cerebellar Abiotrophy in Angus Cattle.Animal genetics · 2026Article
- Case Report: Integrated imaging and molecular diagnostic approach to congenital hip dysplasia in a Hanwoo calf.Frontiers in veterinary science · 2026Article
- Congenital central nervous system malformations in piedmontese calves-part 1. structural brain disorders.Frontiers in veterinary science · 2026Article
- Cattle Abortions and Congenital Malformations Due to Bluetongue Virus Serotype 3 in Southern Belgium, 2024.Viruses · 2025Article
- Bluetongue in ruminants: Global epidemiology, pathogenesis, and advances in diagnostic and control strategies within a One Health framework.Veterinary world · 2025Review
- The Prevalence of Tail Alterations on German Dairy Farms.Animals : an open access journal from MDPI · 2025Article
- An Overview of Developmental Disorders Leading to Dystocia in Cattle.Reproduction in domestic animals = Zuchthygiene · 2025Review
- Cerebral Malformations in Calves Presumed to Be Associated with an Outbreak of Bluetongue Virus Serotype 3 Infection.Animals : an open access journal from MDPI · 2025Article
- Congenital Malformations of the Central Nervous System Caused by Bluetongue Virus Serotype 3 (BTV-3) in Two Calves.Veterinary sciences · 2025Article
- Bovine Congenital Defects Recorded in a National Survey of Dairy and Beef Herds Over Ten Years (2014-2023).Reproduction in domestic animals = Zuchthygiene · 2025Article
- Congenital Oropouche in Humans: Clinical Characterization of a Possible New Teratogenic Syndrome.Viruses · 2025Article
- Vertical transmission potential of Oropouche virus infection in human pregnancies.AJOG global reports · 2025Article
- Isolation and identification of an AKAV strain in dairy cattle in China.Frontiers in veterinary science · 2025Article
- A Review on Reliable and Standardized Animal Models to Study the Pathogenesis of Schmallenberg Virus in Ruminant Natural Host Species.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Review
- Complex neural tube and skeletal malformations, resembling Chiari malformations, in two calves.Veterinary research communications · 2024Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diagnosing the cause of bovine congenital malformations (BCMs) is challenging for bovine veterinary practitioners and laboratory diagnosticians as many known as well as a large number of not-yet reported syndromes exist. Foetal infection with certain viruses, including bovine virus diarrhea virus (BVDV), Schmallenberg virus (SBV), blue tongue virus (BTV), Akabane virus (AKAV), or Aino virus (AV), is associated with a range of congenital malformations. It is tempting for veterinary practitioners to diagnose such infections based only on the morphology of the defective offspring. However, diagnosing a virus as a cause of BCMs usually requires laboratory examination and even in such cases, interpretation of findings may be challenging due to lack of experience regarding genetic defects causing similar lesions, even in cases where virus or congenital antibodies are present. Intrauterine infection of the foetus during the susceptible periods of development, i.e. around gestation days 60-180, by BVDV, SBV, BTV, AKAV and AV may cause malformations in the central nervous system, especially in the brain. Brain lesions typically consist of hydranencephaly, porencephaly, hydrocephalus and cerebellar hypoplasia, which in case of SBV, AKAV and AV infections may be associated by malformation of the axial and appendicular skeleton, e.g. arthrogryposis multiplex congenita. Doming of the calvarium is present in some, but not all, cases. None of these lesions are pathognomonic so diagnosing a viral cause based on gross lesions is uncertain. Several genetic defects share morphology with virus induced congenital malformations, so expert advice should be sought when BCMs are encountered.
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