Evidence map›Paper›PMID 26399507›Full record

ArticleInternational journal of clinical pharmacy2015

Tablet splitting of narrow therapeutic index drugs: a nationwide survey in Taiwan.

Chia-Lin Chou, Chia-Chen Hsu, Chia-Yu Chou, Tzeng-Ji Chen, Li-Fang Chou, Yueh-Ching Chou

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Article in International journal of clinical pharmacy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Chia-Lin ChouDepartment of Pharmacy, Taipei Veterans General Hospital, No. 201, Sec. 2, Shi-Pai Road, Taipei, Taiwan, ROC.
Chia-Chen HsuDepartment of Pharmacy, Taipei Veterans General Hospital, No. 201, Sec. 2, Shi-Pai Road, Taipei, Taiwan, ROC.
Chia-Yu ChouDepartment of Critical Care Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Tzeng-Ji ChenInstitute of Hospital and Health Care Administration, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
Li-Fang ChouDepartment of Public Finance, National Chengchi University, Taipei, Taiwan, ROC.
Yueh-Ching ChouDepartment of Pharmacy, Taipei Veterans General Hospital, No. 201, Sec. 2, Shi-Pai Road, Taipei, Taiwan, ROC. ycchou@vghtpe.gov.tw.
Taipei Veterans General Hospital · TWNational Chengchi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTablet splitting or pill splitting frequently occurs in daily medical practice. For drugs with special pharmacokinetic characters, such as drugs with narrow therapeutic index (NTI), unequal split tablets might lead to erroneous dose titration and it even cause toxicity.

objectiveThe aim of this study was to investigate the frequency of prescribing split NTI drugs at ambulatory setting in Taiwan.

settingA population-based retrospective study was conducted using the National Health Insurance Research Database in Taiwan. All ambulatory visits were analyzed from the longitudinal cohort datasets of the National Health Insurance Research Database.

methodsThe details of ambulatory prescriptions containing NTI drugs were extracted by using the claims datasets of one million beneficiaries from National Healthcare Insurance Research Database in 2010 in Taiwan. The analyses were stratified by dosage form, patient age and the number of prescribed tablets in a single dose for each NTI drugs. Main outcome measures Number and distinct dosage forms of available NTI drug items in Taiwan, number of prescriptions involved split NTI drugs, and number of patients received split NTI drugs.

resultsA total of 148,548 patients had received 512,398 prescriptions of NTI drugs and 41.8 % (n = 62,121) of patients had received 36.3 % (n = 185,936) of NTI drug prescriptions in form of split tablets. The percentage of splitting was highest in digoxin prescriptions (81.0 %), followed by warfarin (72.0 %). In the elderly patients, split tablets were very prevalent with digoxin (82.4 %) and warfarin (84.5 %).

conclusionNTI drugs were frequently prescribed to be taken in split forms in Taiwan. Interventions may be needed to provide effective and convenient NTI drug use. Further studies are needed to evaluate the clinical outcome of inappropriate split NTI drugs.

Indexed as

AdolescentAdultAgedAge FactorsFemaleHumansMaleMiddle AgedNational Health ProgramsPrescription DrugsPrevalenceRetrospective StudiesTabletsTaiwanYoung AdultPrescription DrugsTabletsNarrow therapeutic index drugsPrescribing patternsSplitting frequencyTablet splittingTaiwan

Identifiers

PMID26399507
OpenAlexW1727667300

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.