Evidence map›Paper›PMID 26399452›Full record

SynthesisInternational wound journal2016

The role of adult tissue-derived stem cells in chronic leg ulcers: a systematic review focused on tissue regeneration medicine.

Bruno Amato, Rita Compagna, Maurizio Amato, Lucia Butrico, Francesco Fugetto, Mariia D Chibireva, Andrea Barbetta, Marco Cannistrà, Stefano de Franciscis, Raffaele Serra

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International wound journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. The Efficacy of Stem Cells in Wound Healing: A Systematic Review.International journal of molecular sciences · 2024
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bruno AmatoInteruniversity Center of Phlebolymphology (CIFL). International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Rita CompagnaInteruniversity Center of Phlebolymphology (CIFL). International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Maurizio AmatoDepartment of Clinical Medicine and Surgery, University of Naples "Federico II", Naples, Italy.
Lucia ButricoDepartment of Medical and Surgical Sciences, University of Catanzaro, Catanzaro, Italy.
Francesco FugettoSchool of Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Mariia D ChibirevaSchool of Medicine, Kazan State Medical University, Kazan, Tatarstan Republic, Russian Federation.
Andrea BarbettaDepartment of Medical and Surgical Sciences, University of Catanzaro, Catanzaro, Italy.
Marco CannistràDepartment of Surgery, Annunziata Hospital of Cosenza, Cosenza, Italy.
Stefano de FranciscisInteruniversity Center of Phlebolymphology (CIFL). International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Raffaele SerraInteruniversity Center of Phlebolymphology (CIFL). International Research and Educational Program in Clinical and Experimental Biotechnology, Headquarters, University Magna Graecia of Catanzaro, Catanzaro, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing is an articulated process that can be impaired in different steps in chronic wounds. Chronic leg ulcers are a special type of non-healing wounds that represent an important cause of morbidity and public cost in western countries. Because of their common recurrence after conventional managements and increasing prevalence due to an ageing population, newer approaches are needed. Over the last decade, the research has been focused on innovative treatment strategies, including stem-cell-based therapies. After the initial interest in embryonic pluripotent cells, several different types of adult stem cells have been studied because of ethical issues. Specific types of adult stem cells have shown a high potentiality in tissue healing, in both in vitro and in vivo studies. Aim of this review is to clearly report the newest insights on tissue regeneration medicine, with particular regard for chronic leg ulcers.

Indexed as

Mesenchymal Stem CellsAdultChronic DiseaseFemaleHumansLeg UlcerMaleMesenchymal Stem Cell TransplantationPrognosisRegenerationRoleSeverity of Illness IndexWound HealingAdult tissue-derived stem cellsChronic leg ulcersStem cellsWound healing

Identifiers

PMID26399452
PMCPMC7949523

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.