Evidence map›Paper›PMID 26399430›Full record

ArticleBMC medical research methodology2015

Impact of preconception enrollment on birth enrollment and timing of exposure assessment in the initial vanguard cohort of the U.S. National Children's Study.

Joseph B Stanford, Ruth Brenner, David Fetterer, Leslie Palmer, Kenneth C Schoendorf, U.S. National Children’s Study

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical research methodology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joseph B StanfordDepartment of Family and Preventive Medicine, University of Utah, 375 Chipeta Way, Salt Lake City, UT, 84108, USA. joseph.stanford@utah.edu.
Ruth BrennerEunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA. brennerr@exchange.nih.gov.
David FettererARCBridge Consulting and Training, Herndon, VA, USA. dfed1ster@gmail.com.
Leslie PalmerDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA. leslie.palmer@hsc.utah.edu.
Kenneth C SchoendorfGreenspring Pediatric Associates, Sinai Hospital of Baltimore, Baltimore, MD, USA. k_schoendorf@hotmail.com.
U.S. National Children’s Study

Funding

NICHD NIH HHS HHSN275201100002CNICHD NIH HHS HHSN275201100002GNICHD NIH HHS HHSN275201100003CNICHD NIH HHS HHSN275201100004CNICHD NIH HHS HHSN275201100005CNICHD NIH HHS HHSN275201100007CNICHD NIH HHS HHSN275201100009CNICHD NIH HHS HHSN275201100014CPHS HHS HHSN275200503396CPHS HHS HHSN275200503410CPHS HHS HHSN275200503411CPHS HHS HHSN275200503413CPHS HHS HHSN275200503415CPHS HHS HHSN275200603416CPHS HHS HHSN275201000060UPHS HHS HHSN275201100002CPHS HHS HHSN275201100003CPHS HHS HHSN275201100004CPHS HHS HHSN275201100005CPHS HHS HHSN275201100007CPHS HHS HHSN275201100009CPHS HHS HHSN275201100014CPHS HHS HSN275200503414C
6 · The paper itself

Abstract

backgroundThe initial vanguard cohort of the U.S. National Children's Study was a pregnancy and birth cohort study that sought to enroll some women prior to pregnancy, and to assess exposures early in pregnancy.

methodsDuring the recruitment phase (2009-2010), geographically based sampling was used to recruit women early in pregnancy and women not currently pregnant, not using contraception and heterosexually active. We assessed the following outcomes for women enrolled preconception and early in pregnancy: yield of births; demographic characteristics of births for different enrollment groups; time to pregnancy for preconception women; and the timing of study visits for exposure assessment.

results1399 women were recruited into the initial vanguard cohort: 429 preconception (198 trying for pregnancy, and 231 not trying) and 970 already pregnant. There were 1135 pregnancies (81% of women) and 922 newborns enrolled (81% of pregnancies) through September 2012. Preconception women represented 30.6% of women enrolled, and contributed 14.5% of births. Among women who gave birth, and who had enrolled preconception trying for pregnancy, 67.3% were white non-Hispanic, compared to 50.0% of preconception women not trying for pregnancy, and 61.5% of pregnant women. Women enrolled preconception who were trying for pregnancy had higher cumulative probability of pregnancy at one year compared to women not trying (adjusted 86% versus 56%). Of 165 women enrolled preconception who became pregnant, 19% had a study visit within 30 days of conception. By 10.5 weeks after conception, 75% of women enrolled preconception had completed a pregnancy study visit; for women enrolled pregnant, the 75% threshold was reached at 28.4 weeks.

conclusionsThere were demographic differences in births from women enrolled preconception trying for pregnancy, preconception not trying for pregnancy, or during pregnancy. Time to pregnancy was shorter for women actively trying for pregnancy. Most women enrolled preconception did not have exposure assessment within 30 days of conception, but they did have exposure assessment much earlier during pregnancy than women who enrolled during pregnancy.

Indexed as

Environmental ExposurePatient SelectionAdolescentAdultCohort StudiesFemaleHealth Impact AssessmentHumansPregnancyYoung Adult

Identifiers

PMID26399430
PMCPMC4581516

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.