Evidence map›Paper›PMID 26399406›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2016

Revisiting classification of pain from bone metastases as mild, moderate, or severe based on correlation with function and quality of life.

Edward Chow, Keyue Ding, Wendy R Parulekar, Rebecca K S Wong, Yvette M van der Linden, Daniel Roos, William F Hartsell, Peter Hoskin, Jackson S Y Wu, Abdenour Nabid and 8 more

Abstract read
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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Quality of life, pain, and psychological factors in patients undergoing surgery for primary tumors of the spine.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
  7. An in-hospital clinical care pathway with integrated decision support for cancer pain management reduced pain intensity and needs for hospital stay.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Article
  8. Classification of painful bone metastases as mild, moderate, or severe using both EORTC QLQ-C15-PAL and EORTC QLQ-BM22.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Edward ChowSunnybrook Odette Cancer Centre, University of Toronto, Toronto, ON, Canada. Edward.Chow@sunnybrook.ca.
Keyue DingNCIC Clinical Trials Group, Cancer Research Institute, Queen's University, Kingston, ON, Canada.
Wendy R ParulekarNCIC Clinical Trials Group, Cancer Research Institute, Queen's University, Kingston, ON, Canada.
Rebecca K S WongPrincess Margaret Cancer Centre, Radiation Medicine Program, Ontario Cancer Institute, University of Toronto, Toronto, ON, Canada.
Yvette M van der LindenLeiden University Medical Centre, Leiden and Radiotherapy Institute Friesland, Leeuwarden, Netherlands.
Daniel RoosRoyal Adelaide Hospital, University of Adelaide, Adelaide, Australia.
William F HartsellCentral DuPage Hospital Cancer Center, Warrenville, IL, USA.
Peter HoskinMount Vernon Hospital Cancer Centre, Middlesex, UK.
Jackson S Y WuTom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada.
Abdenour NabidCentre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Francisca OngMedisch Spectrum Twente, Enschede, Netherlands.
Geertjan van TienhovenAcademic Medical Center, Amsterdam, Netherlands.
Scott BabingtonChristchurch Hospital, Christchurch, New Zealand.
William F DemasAkron City Hospital, Northeast Ohio Medical University, Akron, OH, USA.
Carolyn F WilsonNCIC Clinical Trials Group, Cancer Research Institute, Queen's University, Kingston, ON, Canada.
Michael BrundageQueen's University, Kingston, ON, Canada.
Liting ZhuNCIC Clinical Trials Group, Cancer Research Institute, Queen's University, Kingston, ON, Canada.
Ralph M MeyerJuravinski Hospital and Cancer Centre and McMaster University, Hamilton, ON, Canada.

Funding

RTOG Foreign AccrualU10CA021661 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI CURRAN, WALTER J. · 1985 to 2013
$150.3M
RTOG Foreign AccrualsU10CA037422 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI BRUNER, DEBORAH WATKINS · 1985 to 2013
$30.4M
NCI NIH HHS U10 CA21661NCI NIH HHS U10 CA37422
6 · The paper itself

Abstract

purposeThe objective of our study was to determine the optimal cut points for classification of pain scores as mild, moderate, and severe based on interference with function and quality of life (QOL).

methodsWe evaluated 822 patients who completed the Brief Pain Inventory (BPI) and/or the European Organization for Research and Treatment of Cancer (EORTC) QOL Questionnaire Core 30 (QLQ-C30) prior to receiving repeat radiation therapy for previously irradiated painful bone metastases. Optimal cut points for mild, moderate, and severe pain were determined by the MANOVA that yielded the largest F ratio for the between category effect on the seven interference items of BPI and the six functional domains of QOL (physical, role, emotional, cognitive, social functioning, and global QOL) as indicated by Pillai's Trace, Wilk's λ, and Hostelling's Trace F statistics.

resultsFor BPI and for QOL domains separately, the two largest F ratios for Wilk's λ, Pillai's Trace, and Hotelling's Trace F statistics were from the cut points 4, 8 and 6, 8. When combining both, the optimal cut points were 4, 8 with 1-4 (mild), 5-8 (moderate), and 9-10 (severe). With this classification, the mean scores of all the seven interference items in BPI and the six functional domains were all highly statistically different. Patients with severe pain survived significantly shorter than those with mild and moderate pain (p < 0.0001).

conclusionOur analysis supports the classification of pain scores as follows: 1-4 as mild pain, 5-8 as moderate pain, and 9-10 as severe pain. This may facilitate conduct of future clinical trials.

Indexed as

Quality of LifeSeverity of Illness IndexAdolescentAdultAgedAged, 80 and overBone NeoplasmsFemaleHumansMaleMiddle AgedPainPain MeasurementYoung AdultBone metastasesFunctional interferencePain severityQuality of lifeRe-irradiationSurvival

Identifiers

PMID26399406

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.