Trial reportTrials2015
High frequency oscillations in the intra-operative ECoG to guide epilepsy surgery ("The HFO Trial"): study protocol for a randomized controlled trial.
Trial report in Trials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02207673 (Intra-operative Detection and Localisation of High Frequency Oscillations in the ECoG to Guide Epilepsy Surgery), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intra-operative Detection and Localisation of High Frequency Oscillations in the ECoG to Guide Epilepsy Surgery
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of high-frequency oscillations in epilepsy surgery planning.The Cochrane database of systematic reviews · 2017Pooled it
- Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery in the Netherlands (the HFO trial): a randomised, single-blind, adaptive non-inferiority trial.The Lancet. Neurology · 2022Trial
- Brain-Adhesive Bioelectronics With Shape-Morphable and Biodegradable Properties for Stable Brain Signal Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Integration of intraoperative ultrasound and depth-electrode electrocorticography for resection guidance in epilepsy surgery: technical workflow and feasibility.Acta neurochirurgica · 2026Article
- Impact of Anesthesia With Propofol on Epileptic Discharges Recorded by Stereo-Electroencephalography in Pediatric Epilepsy Surgery.CNS neuroscience & therapeutics · 2026Article
- High frequency oscillation network dynamics predict outcome in non-palliative epilepsy surgery.Brain communications · 2024Article
- Characterizing physiological high-frequency oscillations using deep learning.Journal of neural engineering · 2022Article
- Effect of Training on Visual Identification of High Frequency Oscillations-A Delphi-Style Intervention.Frontiers in neurology · 2022Article
- The spatial relationship between the MRI lesion and intraoperative electrocorticography in focal epilepsy surgery.Brain communications · 2022Article
- A multi-head self-attention deep learning approach for detection and recommendation of neuromagnetic high frequency oscillations in epilepsy.Frontiers in neuroinformatics · 2022Article
- Accuracy of high-frequency oscillations recorded intraoperatively for classification of epileptogenic regions.Scientific reports · 2021Article
- A spiking neural network (SNN) for detecting high frequency oscillations (HFOs) in the intraoperative ECoG.Scientific reports · 2021Article
- Are HFOs in the Intra-operative ECoG Related to Hippocampal Sclerosis, Volume and IQ?Frontiers in neurology · 2021Article
- Epileptic High-Frequency Oscillations in Intracranial EEG Are Not Confounded by Cognitive Tasks.Frontiers in human neuroscience · 2021Article
- The value of intra-operative electrographic biomarkers for tailoring during epilepsy surgery: from group-level to patient-level analysis.Scientific reports · 2020Article
- DC shifts, high frequency oscillations, ripples and fast ripples in relation to the seizure onset zone.Seizure · 2020Review
- High-frequency oscillations in scalp EEG mirror seizure frequency in pediatric focal epilepsy.Scientific reports · 2019Article
- Changing concepts in presurgical assessment for epilepsy surgery.Nature reviews. Neurology · 2019Review
- Localization of the Epileptogenic Zone Using High Frequency Oscillations.Frontiers in neurology · 2019Review
- A Stacked Sparse Autoencoder-Based Detector for Automatic Identification of Neuromagnetic High Frequency Oscillations in Epilepsy.IEEE transactions on medical imaging · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntra-operative electrocorticography, based on interictal spikes and spike patterns, is performed to optimize delineation of the epileptogenic tissue during epilepsy surgery. High frequency oscillations (HFOs, 80-500 Hz) have been identified as more precise biomarkers for epileptogenic tissue. The aim of the trial is to determine prospectively if ioECoG-tailored surgery using HFOs, instead of interictal spikes, is feasible and will lead to an equal or better seizure outcome. METHODS\
designWe present a single-blinded multi-center randomized controlled trial "The HFO Trial" including patients with refractory focal epilepsy of all ages who undergo surgery with intra-operative electrocorticography. Surgery is tailored by HFOs (arm 1) or interictal spikes (arm 2) in the intra-operative electrocorticography. Primary outcome is post-operative outcome after 1 year, dichotomized in seizure freedom (Engel 1A and 1B) versus seizure recurrence (Engel 1C-4). Secondary outcome measures are the volume of resected tissue, neurologic deficits, surgical duration and complications, cognition and quality of life. The trial has a non-inferiority design to test feasibility and at least equal performance in terms of surgical outcome. We aim to include 78 patients within 3 years including 1 year follow-up. Results are expected in 2018. DISCUSSION: This trial provides a transition from observational research towards clinical interventions using HFOs. We address methodological difficulties in designing this trial. We expect that the use of HFOs as a biomarker for tailoring will increase the success rate of epilepsy surgery while reducing resection volume. This may reduce neurological deficits and yield a better quality of life. Future technical developments, such as validated automatic online HFO identification, could, together with the attained clinical knowledge, lead to a new objective tailoring approach in epilepsy surgery.
trial registrationThis trial is registered at the US National Institutes of Health (ClinicalTrials.gov) #NCT02207673 (31 July 2014) and the Central Committee on Research Involving Human Subjects, The Netherlands #NL44257.041.13 (18 March 2014).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.