Evidence map›Paper›PMID 26399249›Full record

ReviewNeurocritical care2016

Vagus Nerve Stimulation and Other Neuromodulation Methods for Treatment of Traumatic Brain Injury.

Daniel Neren, Matthew D Johnson, Wynn Legon, Salam P Bachour, Geoffrey Ling, Afshin A Divani

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Neurocritical care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04071743 (A Randomized, Single-Center, Double-Blind, Parallel, Sham-Controlled Study of Gammacore Sapphire), which is not on this map. Cited by 44 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04071743 nawithdrawnnot on this mapstarted 2020, after this paper: background citation

A Randomized, Single-Center, Double-Blind, Parallel, Sham-Controlled Study of Gammacore Sapphire (Non-Invasive Vagus Nerve Stimulator) for the Acute and Preventive Treatment of Post-Traumatic Headache (GAP-PTH)

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2020 to 2021Enrolled0ConditionsPost-Traumatic HeadacheArmsgammaCore Sapphire, sham gammaCore Sapphire
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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  18. Immune Response in Traumatic Brain Injury.Current neurology and neuroscience reports · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Daniel NerenDepartment of Neurology, University of Minnesota, 420 Delaware Street S.E., MMC 295, Minneapolis, MN, 55455, USA.
Matthew D JohnsonDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Wynn LegonDepartment of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, MN, USA.
Salam P BachourDepartment of Neurology, University of Minnesota, 420 Delaware Street S.E., MMC 295, Minneapolis, MN, 55455, USA.
Geoffrey LingDepartment of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Afshin A DivaniDepartment of Neurology, University of Minnesota, 420 Delaware Street S.E., MMC 295, Minneapolis, MN, 55455, USA. adivani@gmail.com.
University of Minnesota · USUniformed Services University of the Health Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this paper is to review the current literature regarding the use of vagus nerve stimulation (VNS) in preclinical models of traumatic brain injury (TBI) as well as discuss the potential role of VNS along with alternative neuromodulation approaches in the treatment of human TBI. Data from previous studies have demonstrated VNS-mediated improvement following TBI in animal models. In these cases, VNS was observed to enhance motor and cognitive recovery, attenuate cerebral edema and inflammation, reduce blood brain barrier breakdown, and confer neuroprotective effects. Yet, the underlying mechanisms by which VNS enhances recovery following TBI remain to be fully elucidated. Several hypotheses have been offered including: a noradrenergic mechanism, reduction in post-TBI seizures and hyper-excitability, anti-inflammatory effects, attenuation of blood-brain barrier breakdown, and cerebral edema. We present other potential mechanisms by which VNS acts including enhancement of synaptic plasticity and recruitment of endogenous neural stem cells, stabilization of intracranial pressure, and interaction with the ghrelin system. In addition, alternative methods for the treatment of TBI including deep brain stimulation, transcranial magnetic stimulation, transcranial direct current stimulation, and focused ultrasound stimulation are discussed. Although the primary source data show that VNS improves TBI outcomes, it remains to be determined if these findings can be translated to clinical settings.

Indexed as

Ultrasonic WavesAnimalsBrain Injuries, TraumaticElectric Stimulation TherapyHumansVagus Nerve StimulationDeep brain stimulationNeuromodulationTraumatic brain injuryUltrasoundVagus nerve stimulation

Identifiers

PMID26399249
OpenAlexW2190133364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.