ArticleBrain imaging and behavior2016
The effect of age and microstructural white matter integrity on lap time variation and fast-paced walking speed.
Article in Brain imaging and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The brain map of gait variability in aging, cognitive impairment and dementia-A systematic review.Neuroscience and biobehavioral reviews · 2017Pooled it
- Tooth loss is associated with subsequent brain white matter degradation up to over a decade.Journal of dentistry · 2026Article
- Early Microstructural Changes in the Left Inferior Fronto-Occipital Fasciculus: A Key Factor in Probable Alzheimer's Disease Patients With Slow Gait Speed.Brain and behavior · 2026Article
- Higher skeletal muscle mitochondrial oxidative capacity is associated with preserved brain structure up to over a decade.Nature communications · 2024Article
- Neuroprotective effects of rosemary extract on white matter of prefrontal cortex in old rats.Iranian journal of basic medical sciences · 2024Article
- Lower Myelin Content Is Associated With Lower Gait Speed in Cognitively Unimpaired Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Motor and Physical Function Impairments as Contributors to Slow Gait Speed and Mobility Difficulty in Middle-Aged and Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Longitudinal associations of absolute versus relative moderate-to-vigorous physical activity with brain microstructural decline in aging.Neurobiology of aging · 2022Article
- Differential Relationships Between Brain Structure and Dual Task Walking in Young and Older Adults.Frontiers in aging neuroscience · 2022Article
- Sarcopenia and Neuroscience: Learning to Communicate.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Neuroimaging correlates of gait abnormalities in progressive supranuclear palsy.NeuroImage. Clinical · 2021Article
- Microstructural Neuroimaging of Frailty in Cognitively Normal Older Adults.Frontiers in medicine · 2020Article
- Lap Time Variability From a 400-m Walk Is Associated With Future Mild Cognitive Impairment and Alzheimer's Disease.Journal of the American Medical Directors Association · 2019Article
- Brain White Matter: A Substrate for Resilience and a Substance for Subcortical Small Vessel Disease.Brain sciences · 2019Article
- Vascular burden and APOE ε4 are associated with white matter microstructural decline in cognitively normal older adults.NeuroImage · 2019Article
- Associations of Musculoskeletal Pain With Mobility in Older Adults: Potential Cerebral Mechanisms.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Olfaction Is Related to Motor Function in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- The Vanderbilt Memory & Aging Project: Study Design and Baseline Cohort Overview.Journal of Alzheimer's disease : JAD · 2016Article
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Authors and funding
9 authors.
Funding
Abstract
Macrostructural white matter damage (WMD) is associated with less uniform and slower walking in older adults. The effect of age and subclinical microstructural WM degeneration (a potentially earlier phase of WM ischemic damage) on walking patterns and speed is less clear. This study examines the effect of age on the associations of regional microstructural WM integrity with walking variability and speed, independent of macrostructural WMD. This study involved 493 participants (n = 51 young; n = 209 young-old; n = 233 old-old) from the Baltimore Longitudinal Study of Aging. All completed a 400-meter walk test and underwent a concurrent brain MRI with diffusion tensor imaging. Microstructural WM integrity was measured as fractional anisotropy (FA). Walking variability was measured as trend-adjusted variation in time over ten 40-meter laps (lap time variation, LTV). Fast-paced walking speed was assessed as mean lap time (MLT). Multiple linear regression models of FA predicting LTV and MLT were adjusted for age, sex, height, weight, and WM hyperintensities. Independent of WM hyperintensities, lower FA in the body of the corpus callosum was associated with higher LTV and longer MLT only in the young-old. Lower FA in superior longitudinal, inferior fronto-occipital, and uncinate fasciculi, the anterior limb of the internal capsule, and the anterior corona radiate was associated with longer MLT only in the young-old. While macrostructural WMD is known to predict more variable and slower walking in older adults, microstructural WM disruption is independently associated with more variable and slower fast-paced walking only in the young-old. Disrupted regional WM integrity may be a subclinical contributor to abnormal walking at an earlier phase of aging.
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