ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2016
Genetic associations with viral respiratory illnesses and asthma control in children.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Bacterial-Derived Immunomodulators as a Preventive Strategy for Viral Respiratory Tract Infections and Associated Wheezing or Asthma in Children: A Targeted Narrative Review.Children (Basel, Switzerland) · 2026Review
- Integrated nasopharyngeal airway metagenome and asthma genetic risk endotyping of severe bronchiolitis in infancy and risk of childhood asthma.The European respiratory journal · 2024Article
- Association of Asthma Risk Alleles With Acute Respiratory Tract Infections and Wheezing Illnesses in Young Children.The Journal of infectious diseases · 2023Article
- Likelihood of hospitalization for a chronic respiratory condition following pediatric infection with enterovirus and rhinovirus strains.Infectious medicine · 2022Article
- Viral Infection and Airway Epithelial Immunity in Asthma.International journal of molecular sciences · 2022Review
- Risk factors for severe adult-onset asthma: a multi-factor approach.BMC pulmonary medicine · 2021Article
- Up-Regulated Vitamin D Receptor byPharmaceuticals (Basel, Switzerland) · 2021Article
- Viral Induced Effects on a Vulnerable Epithelium; Lessons Learned From Paediatric Asthma and Eosinophilic Oesophagitis.Frontiers in immunology · 2021Review
- Molecular mechanisms and epidemiology of COVID-19 from an allergist's perspective.The Journal of allergy and clinical immunology · 2020Review
- Genetic Signatures of Acute Asthma Exacerbation Related With Ineffective Response to Corticosteroid.Allergy, asthma & immunology research · 2020Article
- Genetic determinants of host immunity against human rhinovirus infections.Human genetics · 2020Review
- Evolving concepts in how viruses impact asthma: A Work Group Report of the Microbes in Allergy Committee of the American Academy of Allergy, Asthma & Immunology.The Journal of allergy and clinical immunology · 2020Article
- Article
- Rhinovirus and Asthma Exacerbations.Immunology and allergy clinics of North America · 2019Review
- Respiratory health, allergies, and the farm environment: design, methods and enrollment in the observational Wisconsin Infant Study Cohort (WISC): a research proposal.BMC research notes · 2019Article
- Asthma exacerbations in a subtropical area and the role of respiratory viruses: a cross-sectional study.BMC pulmonary medicine · 2018Article
- Gene-Environment Interactions Associated with the Severity of Acute Asthma Exacerbation in Children.American journal of respiratory and critical care medicine · 2018Article
- A rare IL33 loss-of-function mutation reduces blood eosinophil counts and protects from asthma.PLoS genetics · 2017Article
- The puzzle of immune phenotypes of childhood asthma.Molecular and cellular pediatrics · 2016Review
- Retrospective cohort analysis of healthcare claims in the United States characterising asthma exacerbations in paediatric patients.The World Allergy Organization journal · 2016Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundViral respiratory infections can cause acute wheezing illnesses in children and exacerbations of asthma.
objectiveWe sought to identify variation in genes with known antiviral and pro-inflammatory functions to identify specific associations with more severe viral respiratory illnesses and the risk of virus-induced exacerbations during the peak fall season.
methodsThe associations between genetic variation at 326 SNPs in 63 candidate genes and 10 phenotypes related to viral respiratory infection and asthma control were examined in 226 children enrolled in the RhinoGen study. Replication of asthma control phenotypes was performed in 2128 children in the Copenhagen Prospective Study on Asthma in Childhood (COPSAC). Significant associations in RhinoGen were further validated using virus-induced wheezing illness and asthma phenotypes in an independent sample of 122 children enrolled in the Childhood Origins of Asthma (COAST) birth cohort study.
resultsA significant excess of P values smaller than 0.05 was observed in the analysis of the 10 RhinoGen phenotypes. Polymorphisms in 12 genes were significantly associated with variation in the four phenotypes showing a significant enrichment of small P values. Six of those genes (STAT4, JAK2, MX1, VDR, DDX58, and EIF2AK2) also showed significant associations with asthma exacerbations in the COPSAC study or with asthma or virus-induced wheezing phenotypes in the COAST study.
conclusionsWe identified genetic factors contributing to individual differences in childhood viral respiratory illnesses and virus-induced exacerbations of asthma. Defining mechanisms of these associations may provide insight into the pathogenesis of viral respiratory infections and virus-induced exacerbations of asthma.
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