Evidence map›Paper›PMID 26399219›Full record

ArticleGenetic epidemiology2015

Epithelial-Mesenchymal Transition (EMT) Gene Variants and Epithelial Ovarian Cancer (EOC) Risk.

Ernest K Amankwah, Hui-Yi Lin, Jonathan P Tyrer, Kate Lawrenson, Joe Dennis, Ganna Chornokur, Katja K H Aben, Hoda Anton-Culver, Natalia Antonenkova, Fiona Bruinsma and 148 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetic epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Germline Mutations in 12 Genes and Risk of Ovarian Cancer in Three Population-Based Cohorts.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
  3. Article
  4. The Role of Glypicans in Cancer Progression and Therapy.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
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  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

158 authors at 20 institutions in 16 countries.

Ernest K AmankwahDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
Hui-Yi LinDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America.
Jonathan P TyrerCentre for Cancer Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.
Kate LawrensonNorris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Joe DennisCentre for Cancer Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.
Ganna ChornokurDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
Katja K H AbenDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Hoda Anton-CulverGenetic Epidemiology Research Institute, UCI Center for Cancer Genetics Research and Prevention, Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California, United States of America.
Natalia AntonenkovaByelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N, Minsk, Belarus.
Fiona BruinsmaCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Elisa V BanderaCancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America.
Yukie T BeanDepartment of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America.
Matthias W BeckmannErlangen-Nuremberg Comprehensive Cancer Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen EMN, Germany.
Maria BisognaGynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, United States of America.
Line BjorgeDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Natalia BogdanovaRadiation Oncology Research Unit, Hannover Medical School, Hannover, Germany.
Louise A BrintonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
Angela Brooks-WilsonCanada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
Clareann H BunkerDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America.
Ralf ButzowDepartment of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, HUS, Finland.
Ian G CampbellCancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia.
Karen CartyDepartment of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, United Kingdom.
Zhihua ChenDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America.
Y Ann ChenDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Linda S CookDivision of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, United States of America.
Daniel W CramerObstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Julie M CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Agnieszka Dansonka-MieszkowskaDepartment of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Andreas du BoisDepartment of Gynaecology and Gynaecologic Oncology, Kliniken Essen-Mitte/Evang. Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany.
Evelyn DespierreDivision of Gynecologic Oncology, Leuven Cancer Institute, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
Ed DicksCentre for Cancer Epidemiology, Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.
Jennifer A DohertyDepartment of Community and Family Medicine, Section of Biostatistics & Epidemiology, Dartmouth Medical School, Hanover, New Hampshire, United States of America.
Thilo DörkRadiation Oncology Research Unit, Hannover Medical School, Hannover, Germany.
Matthias DürstDepartment of Gynecology, Friedrich Schiller University, Jena, Germany.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Diana M EcclesWessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom.
Robert P EdwardsOvarian Cancer Center of Excellence, Department of Obstetrics Gynecology/RS, Division of Gynecological Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
Arif B EkiciInstitute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Peter A FaschingErlangen-Nuremberg Comprehensive Cancer Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen EMN, Germany.
Brooke L FridleyBiostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, United States of America.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Aleksandra Gentry-MaharajWomen's Cancer, UCL EGA Institute for Women's Health, London, United Kingdom.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Rosalind GlasspoolCRUK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
Marc T GoodmanCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Jacek GronwaldInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Patricia HarringtonCentre for Cancer Epidemiology, Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.
Philipp HarterDepartment of Gynaecology and Gynaecologic Oncology, Kliniken Essen-Mitte/Evang. Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany.
Hanis N HasmadCancer Research Initiatives Foundation, Sime Darby Medical Center, Subang Jaya, Malaysia.
Alexander HeinErlangen-Nuremberg Comprehensive Cancer Center, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University, Erlangen EMN, Germany.
Florian HeitzDepartment of Gynaecology and Gynaecologic Oncology, Kliniken Essen-Mitte/Evang. Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany.
Michelle A T HildebrandtDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Peter HillemannsRadiation Oncology Research Unit, Hannover Medical School, Hannover, Germany.
Claus K HogdallDepartment of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Estrid HogdallDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Satoyo HosonoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
Edwin S IversenDepartment of Statistics, Duke University, Durham, North Carolina, United States of America.
Anna JakubowskaInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Allan JensenDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Bu-Tian JiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
Beth Y KarlanWomen's Cancer Program at the Samuel Oschin Comprehensive, Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Heather JimDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Forida, United States of America.
Melissa KellarDepartment of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America.
Lambertus A KiemeneyDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Camilla KrakstadDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Susanne K KjaerDepartment of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Jolanta KupryjanczykDepartment of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Diether LambrechtsVesalius Research Center, VIB, University of Leuven, Leuven, Belgium.
Sandrina LambrechtsDivision of Gynecologic Oncology, Leuven Cancer Institute, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
Nhu D LeCancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
Alice W LeeNorris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Shashi LeleDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America.
Arto LeminenDepartment of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, HUS, Finland.
Jenny LesterWomen's Cancer Program at the Samuel Oschin Comprehensive, Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Douglas A LevineGynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, United States of America.
Dong LiangCollege of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, United States of America.
Boon Kiong LimDepartment of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Karen LuDepartment of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Jan LubinskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Lene LundvallDepartment of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Leon F A G MassugerRadboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.
Keitaro MatsuoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi, Japan.
Valerie McGuireDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America.
John R McLaughlinPublic Health Ontario, Toronto, Ontario, Canada.
Ian McNeishCRUK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
Usha MenonWomen's Cancer, UCL EGA Institute for Women's Health, London, United Kingdom.
Roger L MilneCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Francesmary ModugnoDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, United States of America.
Kirsten B MoysichDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America.
Roberta B NessSchool of Public Health, The University of Texas, Houston, Texas, United States of America.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, HUS, Finland.
Ursula EilberDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kunle OdunsiDepartment of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, United States of America.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, United States of America.
Irene OrlowDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, United States of America.
Sandra OrsulicWomen's Cancer Program at the Samuel Oschin Comprehensive, Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Rachel Palmieri WeberDepartment of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, United States of America.
James PaulCRUK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
Celeste L PearceNorris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Tanja PejovicDepartment of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, United States of America.
Liisa M PelttariDepartment of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, HUS, Finland.
Jennifer Permuth-WeyDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
Malcolm C PikeNorris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Elizabeth M PooleChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, United States of America.
Barry RosenDepartment of Gynecology-Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada.
Mary Anne RossingProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washigton, United States of America.
Joseph H RothsteinDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America.
Anja RudolphDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ingo B RunnebaumDepartment of Gynecology, Friedrich Schiller University, Jena, Germany.
Iwona K RzepeckaDepartment of Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Helga B SalvesenDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Eva SchernhammerChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Ira SchwaabInstitut für Humangenetik, Wiesbaden, Germany.
Xiao-Ou ShuEpidemiology Center and Vanderbilt, Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennesse, United States of America.
Yurii B ShvetsovCancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, United States of America.
Nadeem SiddiquiDepartment of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, United Kingdom.
Weiva SiehDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America.
Honglin SongCentre for Cancer Epidemiology, Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.
Melissa C SoutheyDepartment of Pathology, University of Melbourne, Parkville, Victoria, Australia.
Beata SpiewankiewiczDepartment of Gynecologic Oncology, Institute of Oncology, Warsaw, Poland.
Lara Sucheston-CampbellDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America.
Soo-Hwang TeoCancer Research Initiatives Foundation, Sime Darby Medical Center, Subang Jaya, Malaysia.
Kathryn L TerryObstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Pamela J ThompsonCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Lotte ThomsenDepartment of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Ingvild L TangenDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
Shelley S TworogerObstetrics and Gynecology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
Anne M van AltenaRadboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.
Robert A VierkantDepartment of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America.
Ignace VergoteDivision of Gynecologic Oncology, Leuven Cancer Institute, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
Christine S WalshWomen's Cancer Program at the Samuel Oschin Comprehensive, Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America.
Shan Wang-GohrkeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
Alice S WhittemoreDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, California, United States of America.
Kristine G WicklundProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washigton, United States of America.
Lynne R WilkensCancer Epidemiology Program, University of Hawaii Cancer Center, Hawaii, United States of America.
Anna H WuNorris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Xifeng WuDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America.
Yin-Ling WooDepartment of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
Hannah YangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America.
Wei ZhengVanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennesse, United States of America.
Argyrios ZiogasGenetic Epidemiology Research Institute, UCI Center for Cancer Genetics Research and Prevention, Department of Epidemiology, School of Medicine, University of California Irvine, Irvine, California, United States of America.
Linda E KelemenDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America.
Andrew BerchuckDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, United States of America.
Georgia Chenevix-Trench on behalf of the AOCS management group
Joellen M SchildkrautCancer Prevention, Detection & Control Research Program, Duke Cancer Institute, Durham, North Carolina, United States of America.
Susan J RamusNorris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Ellen L GoodeDepartment of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, United States of America.
Alvaro N A MonteiroDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida, United States of America.
Simon A GaytherNorris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Steven A NarodWomen's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
Catherine M PhelanDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.
Moffitt Cancer Center · USUniversity of Southern California · USCedars-Sinai Medical Center · USUniversity of Cambridge · GBBrigham and Women's Hospital · USUniversity of Copenhagen · DKBeatson West of Scotland Cancer Centre · GBGerman Cancer Research Center · DEHaukeland University Hospital · NOInternational Hereditary Cancer Center · PLMemorial Sloan Kettering Cancer Center · USNational Cancer Institute · USRadboud University Nijmegen · NLStanford University · USThe Maria Sklodowska-Curie National Research Institute of Oncology · PLThe University of Melbourne · AUUniversity of Helsinki · FIHelios Dr. Horst Schmidt Kliniken Wiesbaden · DEMedizinische Hochschule Hannover · DEOregon Health & Science University · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Chang S Chan · 1997 to 2026
$94.5M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI Zhenkun Lou · 2009 to 2026
$37.0M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
Northern California Cooperative Family Registry for Breast CancerU01CA069417 · NCI · NORTHERN CALIFORNIA CANCER CENTER · PI JOHN, ESTHER M. · 1995 to 2010
$22.4M
Cancer Research UK 10124Cancer Research UK 16561Cancer Research UK C490/A10119Cancer Research UK C490/A10124Cancer Research UK C490/A6187CIHR MOP-86727NCI NIH HHS 1K99CA184415-01NCI NIH HHS K07 CA092044NCI NIH HHS K07 CA095666NCI NIH HHS K07 CA143047NCI NIH HHS K22 CA138563NCI NIH HHS K99 CA184415NCI NIH HHS N01 CN025403NCI NIH HHS N01 PC035137NCI NIH HHS N01 PC067010NCI NIH HHS P01 CA017054NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA072720NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA105009NCI NIH HHS P50 CA136393NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA054419NCI NIH HHS R01 CA058598NCI NIH HHS R01 CA058860NCI NIH HHS R01 CA063678NCI NIH HHS R01 CA063682NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA074850NCI NIH HHS R01 CA076016NCI NIH HHS R01-CA076016NCI NIH HHS R01 CA080742NCI NIH HHS R01 CA083918NCI NIH HHS R01 CA087538NCI NIH HHS R01 CA087696NCI NIH HHS R01 CA112523NCI NIH HHS R01 CA114343NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA126841NCI NIH HHS R01 CA136924NCI NIH HHS R01 CA-1491429NCI NIH HHS R01 CA149429NCI NIH HHS R03 CA113148NCI NIH HHS R03 CA115195NCI NIH HHS R25 CA147832NCI NIH HHS R25T CA147832NCI NIH HHS U01 CA049449NCI NIH HHS U01 CA058860NCI NIH HHS U01 CA067262NCI NIH HHS U01 CA069417NCI NIH HHS U19 CA148112NCI NIH HHS UM1 CA182910NIEHS NIH HHS T32 ES013678NIEHS NIH HHS T32ES013678
6 · The paper itself

Abstract

Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells assume mesenchymal characteristics to facilitate cancer metastasis. However, EMT also contributes to the initiation and development of primary tumors. Prior studies that explored the hypothesis that EMT gene variants contribute to epithelial ovarian carcinoma (EOC) risk have been based on small sample sizes and none have sought replication in an independent population. We screened 15,816 single-nucleotide polymorphisms (SNPs) in 296 genes in a discovery phase using data from a genome-wide association study of EOC among women of European ancestry (1,947 cases and 2,009 controls) and identified 793 variants in 278 EMT-related genes that were nominally (P < 0.05) associated with invasive EOC. These SNPs were then genotyped in a larger study of 14,525 invasive-cancer patients and 23,447 controls. A P-value <0.05 and a false discovery rate (FDR) <0.2 were considered statistically significant. In the larger dataset, GPC6/GPC5 rs17702471 was associated with the endometrioid subtype among Caucasians (odds ratio (OR) = 1.16, 95% CI = 1.07-1.25, P = 0.0003, FDR = 0.19), whereas F8 rs7053448 (OR = 1.69, 95% CI = 1.27-2.24, P = 0.0003, FDR = 0.12), F8 rs7058826 (OR = 1.69, 95% CI = 1.27-2.24, P = 0.0003, FDR = 0.12), and CAPN13 rs1983383 (OR = 0.79, 95% CI = 0.69-0.90, P = 0.0005, FDR = 0.12) were associated with combined invasive EOC among Asians. In silico functional analyses revealed that GPC6/GPC5 rs17702471 coincided with DNA regulatory elements. These results suggest that EMT gene variants do not appear to play a significant role in the susceptibility to EOC.

Indexed as

Genetic Predisposition to DiseaseAdultAgedCarcinoma, Ovarian EpithelialEpithelial-Mesenchymal TransitionFemaleGenome-Wide Association StudyGenotypeHumansMiddle AgedNeoplasms, Glandular and EpithelialOdds RatioOvarian NeoplasmsPolymorphism, Single NucleotideRiskWhite Peopleepithelial-mesenchymal transitionovarian cancersingle-nucleotide polymorphisms

Identifiers

PMID26399219
PMCPMC4721602
OpenAlexW2095983229

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.