Trial reportMedical science monitor : international medical journal of experimental and clinical research2015
Constraint-Induced Aphasia Therapy for Treatment of Chronic Post-Stroke Aphasia: A Randomized, Blinded, Controlled Pilot Trial.
Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Speech therapy for poststroke aphasia: a network meta-analysis of randomized controlled trials.PeerJ · 2026Pooled it
- Global research hotspots and trends in constraint-induced movement therapy in rehabilitation over the past 30 years: a bibliometric and visualization study.Frontiers in neurology · 2024Pooled it
- Pooled it
- Pooled it
- Predicting Outcomes of Language Rehabilitation: Prognostic Factors for Immediate and Long-Term Outcomes After Aphasia Therapy.Journal of speech, language, and hearing research : JSLHR · 2023Trial
- Neuroimaging Correlates of Post-Stroke Aphasia Rehabilitation in a Pilot Randomized Trial of Constraint-Induced Aphasia Therapy.Medical science monitor : international medical journal of experimental and clinical research · 2017Trial
- Communication makes intensive language therapy more efficient: a randomized controlled trial in chronic post-stroke aphasia.Brain communications · 2026Article
- Metric comparison of connectome-based lesion-symptom mapping in post-stroke aphasia.Brain communications · 2024Article
- Progress in the clinical application of constraint-induced therapy following stroke since 2014.Frontiers in neurology · 2023Review
- Reversing the Ruin: Rehabilitation, Recovery, and Restoration After Stroke.Current neurology and neuroscience reports · 2022Review
- Lesion correlates of auditory sentence comprehension deficits in post-stroke aphasia.Neuroimage. Reports · 2022Article
- Constraint-induced Aphasia Therapy Improves the Use of Spoken Language and Word-finding Ability in Chronic Subcortical Aphasia: A Case Report.Progress in rehabilitation medicine · 2022Article
- Speech Entrainment for Aphasia Recovery (SpARc) phase II trial design.Contemporary clinical trials communications · 2021Article
- Current Approaches to the Treatment of Post-Stroke Aphasia.Journal of stroke · 2021Review
- Increased Recruitment of Domain-General Neural Networks in Language Processing Following Intensive Language-Action Therapy: fMRI Evidence From People With Chronic Aphasia.American journal of speech-language pathology · 2021Article
- Is Aphasia Treatment Beneficial for the Elderly? A Review of Recent Evidence.Current physical medicine and rehabilitation reports · 2020Article
- Constraint-induced aphasia therapy for patients with aphasia: A systematic review.International journal of nursing sciences · 2020Review
- Constrained-Induced Dysarthria Therapy: Case Report.Annals of rehabilitation medicine · 2019Article
- Treatment Response to a Double Administration of Constraint-Induced Language Therapy in Chronic Aphasia.Journal of speech, language, and hearing research : JSLHR · 2018Article
- Combining rTMS With Intensive Language-Action Therapy in Chronic Aphasia: A Randomized Controlled Trial.Frontiers in neuroscience · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundTo provide a preliminary estimate of efficacy of constraint-induced aphasia therapy (CIAT) when compared to no-intervention in patients with chronic (>1 year) post-stroke aphasia in order to plan an appropriately powered randomized controlled trial (RCT). MATERIAL AND
methodsWe conducted a pilot single-blinded RCT. 24 patients were randomized: 14 to CIAT and 10 to no-intervention. CIAT groups received up to 4 hours/day of intervention for 10 consecutive business days (40 hours or therapy). Outcomes were assessed within 1 week of intervention and at 1 and 12 weeks after intervention and included several linguistic measures and a measure of overall subjective communication abilities (mini-Communicative Abilities Log (mini-CAL)). Clinicians treating patients (CIAT group) did not communicate with other team members to maintain blinding and the testing team members were blinded to treatment group assignment.
resultsOverall, the results of this pilot RCT support the results of previous observational studies that CIAT may lead to improvements in linguistic abilities. At 12 weeks, the treatment group reported better subjective communication abilities (mini-CAL) than the no-intervention group (p=0.019). Other measures trended towards better performance in the CIAT group.
conclusionsIn this pilot RCT intensive language therapy led to an improvement in subjective language abilities. The effects demonstrated allow the design of a definitive trial of CIAT in patients with a variety of post-stroke aphasia types. In addition, our experiences have identified important considerations for designing subsequent trial(s) of CIAT or other interventions for post-stroke aphasia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.