Evidence map›Paper›PMID 26398910›Full record

Trial reportAlzheimer disease and associated disorders

Olfactory Deficits Predict Cognitive Improvement on Donepezil in Patients With Depression and Cognitive Impairment: A Randomized Controlled Pilot Study.

Gregory H Pelton, Laili Soleimani, Steven P Roose, Matthias H Tabert, Davangere P Devanand

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Donepezil Treatment in Patients With Depression and Cognitive Impairment on Stable Antidepressant Treatment: A Randomized Controlled Trial.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2018
    Trial
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Gregory H Pelton*Division of Geriatric Psychiatry, New York State Psychiatric Institute, the Columbia University Medical Center †Department of Psychiatry, Ichan School of Medicine at Mount Sinai, New York, NY.
Laili Soleimani
Steven P Roose
Matthias H Tabert
Davangere P Devanand
Fundación Juan March · ESMount Sinai Hospital · US

Funding

PSYCHOSOCIAL COREP30AG008051 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHAO, YONGZHAO · 1990 to 2019
$36.1M
VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LUCHSINGER, JOSE ALEJANDRO · 1989 to 2008
$21.7M
QUESTIONABLE DEMENTIA: COURSE AND PREDICTORS OF OUTCOMER01AG017761 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DEVANAND, DAVANGERE P · 2000 to 2012
$7.3M
Olfactory deficits and donepezil treatment in cognitively impaired elderlyR01AG041795 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DEVANAND, DAVANGERE P · 2013 to 2017
$3.2M
Pilot Combination Treatment Trial of Mild Cognitive Impairment with DepressionR01AG040093 · NIA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI DEVANAND, DAVANGERE P · 2011 to 2013
$2.0M
ANTIDEPRESSANT TREATMENT OF MELANCHOLIA IN LATE LIFER01MH055716 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE · PI ROOSE, STEVEN PAUL · 1997 to 2001
$812k
QUESTIONABLE DEMENTIA--COURSE AND PREDICTORS OF OUTCOMER01MH050038 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE · PI DEVANAND, DAVANGERE P · 1994 to 1998
–
NIA NIH HHS AG17761NIA NIH HHS P01 AG007232NIA NIH HHS P30 AG008051NIA NIH HHS R01 AG017761NIA NIH HHS R01 AG040093NIA NIH HHS R01 AG041795NIMH NIH HHS MH55716NIMH NIH HHS R01 MH050038
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedCholinesterase InhibitorsCognitionCognition DisordersDepressionDonepezilFemaleHumansIndansMaleMiddle AgedNeuropsychological TestsOlfaction DisordersPilot ProjectsPiperidinesCholinesterase InhibitorsDonepezilIndansPiperidines

Identifiers

PMID26398910
PMCPMC4764438
OpenAlexW2466010201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.