ArticlePloS one2015
Transgenic Citrus Expressing an Arabidopsis NPR1 Gene Exhibit Enhanced Resistance against Huanglongbing (HLB; Citrus Greening).
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 79 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
79 citing papers in PubMed, 196 citations in OpenAlex.
- Selective Autophagy Receptor CsNBR1 Confers Citrus Huanglongbing Resistance by Degrading 'Candidatus Liberibacter Asiaticus' Virulence Effectors.Molecular plant pathology · 2026Article
- Risk Evaluation and Molecular Characterisation of AtNPR1 Transgenic Citrus Lines Tolerant to Citrus Greening Disease.Plant biotechnology journal · 2026Article
- Article
- Targeted gene expression and associated metabolomic insights into Bacillus subtilis LBS5-mediated suppression of Candidatus liberibacter asiaticus in acid lime (Citrus aurantiifolia (christm.) swingle).World journal of microbiology & biotechnology · 2026Article
- NPR1 suppresses Candidatus Liberibacter asiaticus-induced callose and reactive oxygen species accumulation.Plant physiology · 2025Article
- Fight smarter, not harder: NPR1-mediated immune balance in citrus greening disease.Plant physiology · 2025Article
- Identification of HSP70 genes in Diaphorina citri Kuwayama Reveals Their Involvement in Immunity and Development.Molecular biotechnology · 2025Article
- A timeline of discovery and innovation in Arabidopsis.The Plant cell · 2025Article
- Arabidopsis as a model for translational research.The Plant cell · 2025Review
- CRISPR/Cas9-driven double modification of grapevine MLO6-7 imparts powdery mildew resistance, while editing of NPR3 augments powdery and downy mildew tolerance.The Plant journal : for cell and molecular biology · 2025Article
- "Candidatus Liberibacter asiaticus" Infection Induces Citric Acid Accumulation and Immune Responses Mediated by the Transcription Factor CitPH4.Molecular plant pathology · 2025Article
- Early tolerance mechanisms in citrus: transcriptome and hormone profiling of NPR1-mediated responses toFrontiers in plant science · 2025Article
- Innovative strategies for characterizing and managing huanglongbing in citrus.World journal of microbiology & biotechnology · 2024Review
- NPR1, a key immune regulator for plant survival under biotic and abiotic stresses.Molecular cell · 2024Review
- Overexpressing CsSABP2 enhances tolerance to Huanglongbing and citrus canker inFrontiers in plant science · 2024Article
- Article
- Genetic and physiological characteristics ofFrontiers in genome editing · 2024Article
- Citrus threat huanglongbing (HLB) - Could the rootstock provide the cure?Frontiers in plant science · 2024Article
- Gamma-Aminobutyric Acid Supplementation Boosts the Phytohormonal Profile in 'Plants (Basel, Switzerland) · 2023Article
- Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Commercial sweet orange cultivars lack resistance to Huanglongbing (HLB), a serious phloem limited bacterial disease that is usually fatal. In order to develop sustained disease resistance to HLB, transgenic sweet orange cultivars 'Hamlin' and 'Valencia' expressing an Arabidopsis thaliana NPR1 gene under the control of a constitutive CaMV 35S promoter or a phloem specific Arabidopsis SUC2 (AtSUC2) promoter were produced. Overexpression of AtNPR1 resulted in trees with normal phenotypes that exhibited enhanced resistance to HLB. Phloem specific expression of NPR1 was equally effective for enhancing disease resistance. Transgenic trees exhibited reduced diseased severity and a few lines remained disease-free even after 36 months of planting in a high-disease pressure field site. Expression of the NPR1 gene induced expression of several native genes involved in the plant defense signaling pathways. The AtNPR1 gene being plant derived can serve as a component for the development of an all plant T-DNA derived consumer friendly GM tree.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.