ReviewCurrent opinion in cardiology2015
Arterial tortuosity in genetic arteriopathies.
Review in Current opinion in cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Cervical arteries tortuosity and its association with dissection: A systematic review and meta-analysis.Medicine · 2025Pooled it
- A neonatal extra-anatomical bypass for a "corkscrew" descending aorta associated with interrupted right aortic arch.JTCVS techniques · 2026Article
- Article
- Abdominal aortic tortuosity is not associated with other vascular peripheral pathologies or classical cardiovascular risk factors.Scientific reports · 2026Article
- Machine Learning-Based Age Prediction with Feature Subset Selection from Magnetic Resonance Angiography Data.Healthcare informatics research · 2025Article
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- Growth Rate Assessed by Vascular Deformation Mapping Predicts Type B Aortic Dissection in Marfan Syndrome.Journal of the American Heart Association · 2025Article
- Relationship between the Tortuosity of the Extracranial Internal Carotid and Vertebral Arteries on Magnetic Resonance Imaging/Angiography and Vascular Risk Factors in a Japanese Population.Internal medicine (Tokyo, Japan) · 2024Article
- Growth Rate Assessed by Vascular Deformation Mapping predicts Type B Aortic Dissection in Marfan Syndrome.medRxiv : the preprint server for health sciences · 2024Article
- Tortuosity in non-atherosclerotic vascular diseases is associated with age, arterial aneurysms, and hypertension.Orphanet journal of rare diseases · 2024Article
- Arterial Tortuosity Is a Potent Determinant of Safety in Endovascular Therapy for Acute Ischemic Stroke.Stroke (Hoboken, N.J.) · 2024Article
- Echogenomics: Echocardiography in Heritable Aortopathies.Current cardiology reports · 2024Review
- Cervical artery tortuosity-a reliable semi-automated magnetic resonance-based method.Quantitative imaging in medicine and surgery · 2024Article
- Corkscrew Mesenteric Arteries and Tortuous Descending Aorta in Autosomal Recessive Cutis Laxa.Radiology. Cardiothoracic imaging · 2023Article
- Vertebral Tortuosity Is Associated With Increased Rate of Cardiovascular Events in Vascular Ehlers-Danlos Syndrome.Journal of the American Heart Association · 2023Article
- Review
- The Vertebral Artery: A Systematic Review and a Meta-Analysis of the Current Literature.Diagnostics (Basel, Switzerland) · 2023Review
- Pentagalloyl Glucose (PGG) Prevents and Restores Mechanical Changes Caused by Elastic Fiber Fragmentation in the Mouse Ascending Aorta.Annals of biomedical engineering · 2023Article
- Aortic tortuosity in Turner syndrome is associated with larger ascending aorta.The international journal of cardiovascular imaging · 2022Article
- Experimental and Mouse-Specific Computational Models of the Fbln4Cardiovascular engineering and technology · 2022Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewArterial tortuosity is emerging as a common feature in genetically mediated thoracic aortic disease that may be prognostic. This review will summarize recent literature on arterial tortuosity in the setting of genetic arteriopathies. RECENT
findingsAlthough arterial tortuosity has been primarily described in Loeys-Dietz syndrome due to TGFBR1 and TGFBR2 mutations and in arterial tortuosity syndrome due to SLC210A mutations, recent studies that use quantitative measures of tortuosity suggest that tortuosity is present in many other genetic conditions associated with aortic dilation and dissection. The mechanisms of the development of tortuosity in these disorders are not fully understood, but are founded in the concept that there is abnormal, pathologic arterial lengthening in a fixed space, resulting in more tortuous vessels. Further studies suggest that patients with increased arterial tortuosity are at increased risk of adverse cardiovascular events, including aortic surgery, aortic dissection, and death. SUMMARY: Arterial tortuosity is commonly present in genetically mediated aortic disease. Given the suboptimal performance of aortic dimension alone in predicting aortic dissection, quantification of tortuosity may augment the current algorithms for determining risk in patients with aortic disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.