Evidence map›Paper›PMID 26398413›Full record

ReviewCurrent opinion in cardiology2015

Imaging inflammation and neovascularization in atherosclerosis: clinical and translational molecular and structural imaging targets.

Eric A Osborn, Farouc A Jaffer

Abstract readReview
In one paragraph

Review in Current opinion in cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Molecular Imaging in Drug Discovery and Development.Circulation. Cardiovascular imaging · 2018
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eric A OsbornaCardiovascular Research Center, Cardiology Division, Massachusetts General Hospital bCardiology Division, Beth Israel Deaconess Medical Center cCenter for Molecular Imaging Research and Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Farouc A Jaffer

Funding

Harvard Clinical and Translational Science CenterKL2TR001100 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$8.5M
Intravascular Fluorescence Molecular Imaging of Inflammation in AtherosclerosisR01HL108229 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JAFFER, FAROUC AMIN · 2010 to 2014
$2.1M
NIRF-OFDI of Inflammation in Atheroma Progression and Stent ComplicationsR01HL122388 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI JAFFER, FAROUC AMIN · 2015 to 2018
$2.1M
NCATS NIH HHS KL2 TR001100NHLBI NIH HHS R01 HL108229NHLBI NIH HHS R01 HL122388NHLBI NIH HHS R01 HL122388-01A1
6 · The paper itself

Abstract

purpose of reviewThe purpose of this study is to showcase advances in molecular imaging of atheroma biology in living individuals. RECENT

findingsF-fluorodeoxyglucose (FDG) PET/computed tomography (CT) continues to be the predominant molecular imaging approach for clinical applications, particularly in the large arterial beds. Recently, there has been significant progress in imaging of neovascularization and inflammation to delineate high-risk atheroma and to evaluate drug efficacy. In addition, new hardware detection technology and imaging agents are enabling in-vivo imaging of new targets on diverse imaging platforms. SUMMARY: In this review, we present recent exciting developments in molecular and structural imaging of atherosclerotic plaque inflammation and neovascularization. Building upon prior studies, these advances develop key technology that will play an important role in propelling new diagnostic and therapeutic strategies identifying high-risk plaque phenotypes and assessing new plaque stabilization therapies in clinical trials.

Indexed as

AtherosclerosisHumansInflammationLipidsMolecular ImagingNeovascularization, PathologicReproducibility of ResultsLipids

Identifiers

PMID26398413
PMCPMC4632070

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.