ArticlePLoS neglected tropical diseases2015
Prognostic Analysis of Patients with Ebola Virus Disease.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of patient data from the West Africa (2013-16) Ebola virus disease epidemic.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2019Pooled it
- Identification of Host Gene Transcripts by Machine Learning and Their Application to Predict Outcome in Ebola Virus Disease.The Journal of infectious diseases · 2026Article
- Neurological Manifestations in Adult Survivors of Ebola Virus Disease.JAMA neurology · 2026Article
- Statistical learning methods for improving predictive performance in time-dependent survival models.Genomics & informatics · 2025Article
- Bayesian predictive model of Ebola fatality: Tenth Ebola epidemic in the Democratic Republic of the Congo.Journal of public health in Africa · 2025Article
- Evaluation of viral load in patients with Ebola virus disease in Liberia: a retrospective observational study.The Lancet. Microbe · 2022Observational
- A flexible format LAMP assay for rapid detection of Ebola virus.PLoS neglected tropical diseases · 2020Article
- Laboratory Findings, Compassionate Use of Favipiravir, and Outcome in Patients With Ebola Virus Disease, Guinea, 2015-A Retrospective Observational Study.The Journal of infectious diseases · 2019Observational
- Environmental temperature and case fatality of patients with Ebola virus disease in Sierra Leone and Liberia, 2014-2015: a retrospective cohort study.Tropical medicine & international health : TM & IH · 2019Article
- Post-exposure treatments for Ebola and Marburg virus infections.Nature reviews. Drug discovery · 2018Review
- Insights from clinical research completed during the west Africa Ebola virus disease epidemic.The Lancet. Infectious diseases · 2017Review
- The natural history of acute Ebola Virus Disease among patients managed in five Ebola treatment units in West Africa: A retrospective cohort study.PLoS neglected tropical diseases · 2017Article
- The predictor of mortality outcome in adult patients with Ebola virus disease during the 2014-2015 outbreak in Guinea.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Observational
- Predicting Ebola infection: A malaria-sensitive triage score for Ebola virus disease.PLoS neglected tropical diseases · 2017Article
- Predicting Ebola Severity: A Clinical Prioritization Score for Ebola Virus Disease.PLoS neglected tropical diseases · 2017Article
- Molecular mechanisms of Ebola pathogenesis.Journal of leukocyte biology · 2016Review
- Analysis of Diagnostic Findings From the European Mobile Laboratory in Guéckédou, Guinea, March 2014 Through March 2015.The Journal of infectious diseases · 2016Article
- Deaths, late deaths, and role of infecting dose in Ebola virus disease in Sierra Leone: retrospective cohort study.BMJ (Clinical research ed.) · 2016Article
- Transforming Clinical Data into Actionable Prognosis Models: Machine-Learning Framework and Field-Deployable App to Predict Outcome of Ebola Patients.PLoS neglected tropical diseases · 2016Article
- Age and Ebola viral load correlate with mortality and survival time in 288 Ebola virus disease patients.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2016Article
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Authors and funding
16 authors.
Funding
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Abstract
backgroundThe Ebola virus causes an acute, serious illness which is often fatal if untreated. However, factors affecting the survival of the disease remain unclear. Here, we investigated the prognostic factors of Ebola virus disease (EVD) through various statistical models. METHODOLOGY/PRINCIPAL
findingsSixty three laboratory-confirmed EVD patients with relatively complete clinical profiles were included in the study. All the patients were recruited at Jui Government Hospital, Sierra Leone between October 1st, 2014 and January 18th, 2015. We first investigated whether a single clinical presentation would be correlated with the survival of EVD. Log-rank test demonstrated that patients with viral load higher than 10(6) copies/ml presented significantly shorter survival time than those whose viral load were lower than 10(6) copies/ml (P = 0.005). Also, using Pearson chi-square test, we identified that chest pain, coma, and viral load (>10(6) copies/ml) were significantly associated with poor survival of EVD patients. Furthermore, we evaluated the effect of multiple variables on the survival of EVD by Cox proportional hazards model. Interestingly, results revealed that patient's age, symptom of confusion, and viral load were the significantly associated with the survival of EVD cases (P = 0.017, P = 0.002, and P = 0.027, respectively). CONCLUSIONS/SIGNIFICANCE: These results suggest that age, chest pain, coma, confusion and viral load are associated with the prognosis of EVD, in which viral load could be one of the most important factors for the survival of the disease.
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