ArticlePloS one2015
Genome-Wide Association Study for Autism Spectrum Disorder in Taiwanese Han Population.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Effects ofNutrients · 2019Trial
- Neuroimaging endophenotypes reveal underlying mechanisms and genetic factors contributing to progression and development of four brain disorders.Nature biomedical engineering · 2025Article
- Integrative analysis of genetics, epigenetics and RNA expression data reveal three susceptibility loci for smoking behavior in Chinese Han population.Molecular psychiatry · 2024Article
- The genetic landscape of autism spectrum disorder in the Middle Eastern population.Frontiers in genetics · 2024Article
- The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in Drosophila melanogaster.PLoS biology · 2023Article
- Article
- Epigenome-Wide Analysis Reveals DNA Methylation Alteration inChildren (Basel, Switzerland) · 2022Article
- Validation of the Chinese Version of the Autism Diagnostic Interview-Revised in Autism Spectrum Disorder.Neuropsychiatric disease and treatment · 2022Article
- Peripheral Expression ofPsychiatry and clinical psychopharmacology · 2021Article
- Genomics as a Clinical Decision Support Tool: Successful Proof of Concept for Improved ASD Outcomes.Journal of personalized medicine · 2021Article
- Family-Based Genome-Wide Association Study of Autism Spectrum Disorder in Middle Eastern Families.Genes · 2021Article
- The Role of Copy Number Variations andMolecular syndromology · 2021Article
- Transcription factor GLIS3: Critical roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes.Pharmacology & therapeutics · 2020Review
- Genetic Variation and Autism: A Field Synopsis and Systematic Meta-Analysis.Brain sciences · 2020Article
- Integrative analyses indicate an association between ITIH3 polymorphisms with autism spectrum disorder.Scientific reports · 2020Article
- Whole-exome sequencing of lobular endocervical glandular hyperplasia.Oncology letters · 2019Article
- Identification of rare copy number variations reveals PJA2, APCS, SYNPO, and TAC1 as novel candidate genes in Autism Spectrum Disorders.Molecular genetics & genomic medicine · 2019Observational
- Poly(ADP-Ribosylation) in Age-Related Neurological Disease.Trends in genetics : TIG · 2019Review
- GLIS1-3 transcription factors: critical roles in the regulation of multiple physiological processes and diseases.Cellular and molecular life sciences : CMLS · 2018Review
- A Deep Learning Approach for Predicting Antidepressant Response in Major Depression Using Clinical and Genetic Biomarkers.Frontiers in psychiatry · 2018Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutism spectrum disorder (ASD) is a neurodevelopmental disorder with strong genetic components. Several recent genome-wide association (GWA) studies in Caucasian samples have reported a number of gene regions and loci correlated with the risk of ASD--albeit with very little consensus across studies.
methodsA two-stage GWA study was employed to identify common genetic variants for ASD in the Taiwanese Han population. The discovery stage included 315 patients with ASD and 1,115 healthy controls, using the Affymetrix SNP array 6.0 platform for genotyping. Several gene regions were then selected for fine-mapping and top markers were examined in extended samples. Single marker, haplotype, gene-based, and pathway analyses were conducted for associations.
resultsSeven SNPs had p-values ranging from 3.4~9.9*10-6, but none reached the genome-wide significant level. Five of them were mapped to three known genes (OR2M4, STYK1, and MNT) with significant empirical gene-based p-values in OR2M4 (p = 3.4*10(-5)) and MNT (p = 0.0008). Results of the fine-mapping study showed single-marker associations in the GLIS1 (rs12082358 and rs12080993) and NAALADL2 (rs3914502 and rs2222447) genes, and gene-based associations for the OR2M3-OR2T5 (olfactory receptor genes, p = 0.02), and GLIPR1/KRR1 gene regions (p = 0.015). Pathway analyses revealed important pathways for ASD, such as olfactory and G protein-coupled receptors signaling pathways.
conclusionsWe reported Taiwanese Han specific susceptibility genes and variants for ASD. However, further replication in other Asian populations is warranted to validate our findings. Investigation in the biological functions of our reported genetic variants might also allow for better understanding on the underlying pathogenesis of autism.
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