ArticlePloS one2015
Transient Elastography-Based Liver Profiles in a Hospital-Based Pediatric Population in Japan.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04380493 (Special Considerations for the Use of the Transient Elastography Paediatric Probe, Compared to the Standard M Probe, Indirect Serological Markers and Histology), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Special Considerations for the Use of the Transient Elastography Paediatric Probe, Compared to the Standard M Probe, Indirect Serological Markers and Histology
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Technical performance of shear wave elastography for measuring liver stiffness in pediatric and adolescent patients: a systematic review and meta-analysis.European radiology · 2019Pooled it
- Trial
- Elastography as a non-invasive method of screening non-alcoholic fatty liver disease in the adult phenotype of paediatric obstructive sleep apnoea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Prediction of hepatic fibrosis using the aspartate transaminase-to-platelet ratio index in children and adolescents with metabolic dysfunction-associated steatotic liver disease.BMC pediatrics · 2024Article
- Evaluation of Hepatosteatosis-Induced Increase in Fibrosity by Two-Dimensional Shear Wave Elastography in Children with Obesity and Comparison with Healthy Peers.Turkish archives of pediatrics · 2024Article
- Fontan-associated liver disease: the importance of multidisciplinary teamwork in its management.Frontiers in medicine · 2024Review
- Effect of bariatric surgery on NAFLD/NASH: a single-centre observational prospective cohort study.BMJ open · 2023Observational
- Association of maternal obesity and gestational diabetes mellitus with overweight/obesity and fatty liver risk in offspring.World journal of gastroenterology · 2022Article
- Triglyceride to high-density lipoprotein cholesterol ratio is an independent predictor of liver fibrosis among pediatrics non-alcoholic fatty liver disease.Frontiers in endocrinology · 2022Article
- Review
- The Peculiar Trialogue between Pediatric Obesity, Systemic Inflammatory Status, and Immunity.Biology · 2021Review
- Detection of pediatric hepatic steatosis through ultrasound backscattering analysis.European radiology · 2021Article
- Platelet count and abdominal dynamic CT are useful in predicting and screening for gastroesophageal varices after Fontan surgery.PloS one · 2021Article
- Role of the Gut Microbiota in Regulating Non-alcoholic Fatty Liver Disease in Children and Adolescents.Frontiers in nutrition · 2021Review
- Ultrasound Sample Entropy Imaging: A New Approach for Evaluating Hepatic Steatosis and Fibrosis.IEEE journal of translational engineering in health and medicine · 2021Article
- Transient elastography: a novel, non-invasive method for the evaluation of liver stiffness and controlled attenuation parameter in cows.The Journal of veterinary medical science · 2020Article
- Utility and accuracy of transient elastography in determining liver fibrosis: a case-control study.European journal of pediatrics · 2020Article
- The assessment of liver fibrosis in children with obesity on two methods: transient and two dimensional shear wave elastography.Scientific reports · 2019Article
- NAFLD in children: new genes, new diagnostic modalities and new drugs.Nature reviews. Gastroenterology & hepatology · 2019Review
- Usefulness of Transient Elastography for Non-Invasive Diagnosis of Liver Fibrosis in Pediatric Non-Alcoholic Steatohepatitis.Journal of Korean medical science · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsThe utility of transient elastography (FibroScan) is well studied in adults but not in children. We sought to assess the feasibility of performing FibroScans and the characteristics of FibroScan-based liver profiles in Japanese obese and non-obese children.
methodsFibroScan examinations were performed in pediatric patients (age, 1-18 yr) who visited Osaka City University Hospital. Liver steatosis measured by controlled attenuation parameter (CAP), and hepatic fibrosis evaluated as the liver stiffness measurement (LSM), were compared among obese subjects (BMI percentile ≥ 90%), non-obese healthy controls, and non-obese patients with liver disease.
resultsAmong 214 children examined, FibroScans were performed successfully in 201 children (93.9%; median, 11.5 yr; range, 1.3-17.6 yr; 115 male). CAP values (mean ± SD) were higher in the obese group (n = 52, 285 ± 60 dB/m) compared with the liver disease (n = 40, 202 ± 62, P < 0.001) and the control (n = 107, 179 ± 41, P < 0.001) group. LSM values were significantly higher in the obese group (5.5 ± 2.3 kPa) than in the control (3.9 ± 0.9, P < 0.001), but there were no significant differences in LSM between the liver disease group (5.4 ± 4.2) and either the obese or control group. LSM was highly correlated with CAP in the obese group (ρ = 0.511) but not in the control (ρ = 0.129) or liver disease (ρ = 0.170) groups.
conclusionsChildhood obesity carries a high risk of hepatic steatosis associated with increased liver stiffness. FibroScan methodology provides simultaneous determination of CAP and LSM, is feasible in children of any age, and is a non-invasive and effective screening method for hepatic steatosis and liver fibrosis in Japanese obese children.
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